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1. (WO2012109976) USE OF Α-MANGOSTIN IN PREPARATION OF MEDICAMENTS FOR TREATING ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/109976    International Application No.:    PCT/CN2012/071112
Publication Date: 23.08.2012 International Filing Date: 14.02.2012
IPC:
A61K 31/352 (2006.01), A61K 9/20 (2006.01), A61K 9/14 (2006.01), A61K 9/48 (2006.01), A61K 9/19 (2006.01), A61P 25/28 (2006.01)
Applicants: BOMAI LIMITED [CN/CN]; Room 334, Building B, 525 Xixi road, Xihu district Hangzhou, Zhejiang (CN) (For All Designated States Except US).
XIA, Zheng [CN/CN]; (CN) (For US Only)
Inventors: XIA, Zheng; (CN)
Agent: ZHEJIANG HANGZHOU JINTONG PATENT AGENCY CO. LTD; XU, Guanshou 19F, ShengKexie Building, Wulin Square, Xiacheng Hangzhou, Zhejiang 310003 (CN)
Priority Data:
201110040746.1 18.02.2011 CN
Title (EN) USE OF Α-MANGOSTIN IN PREPARATION OF MEDICAMENTS FOR TREATING ALZHEIMER'S DISEASE
(FR) UTILISATION DE LA MANGOSTINE-Α DANS LA PRÉPARATION DE MÉDICAMENTS DESTINÉS À TRAITER LA MALADIE D'ALZHEIMER
(ZH) α-倒捻子素在制备阿尔兹海默氏病药物中的应用
Abstract: front page image
(EN)Disclosed is a use of α-mangostin in the preparation of medicaments for treating Alzheimer's disease. At working concentrations, α-mangostin exhibits an inhibitory effect on Aβ aggregation and deposition, also has an effective neuroprotective effect against neurotoxicity induced by Aβ oligomers, can enhance the normal physiological function of mammal neuronal cells and maintain the normal cellular state of mammal neuronal cells.
(FR)Cette invention concerne une utilisation de la mangostine α dans la préparation de médicaments destinés à traiter la maladie d'Alzheimer. Aux concentrations de travail, la mangostine α manifeste un effet inhibiteur de l'agrégation et des dépôts d'Aβ ainsi qu'un effet neuroprotecteur efficace contre la neurotoxicité induite par les oligomères d'Aβ, peut améliorer la fonction physiologique normale des cellules neuronales de mammifères et maintenir l'état cellulaire normal des cellules neuronales de mammifères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)