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1. (WO2012109624) MONOVALENT AND MULTIVALENT MULTISPECIFIC COMPLEXES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/109624    International Application No.:    PCT/US2012/024765
Publication Date: 16.08.2012 International Filing Date: 10.02.2012
IPC:
C07K 14/78 (2006.01)
Applicants: ZYNGENIA, INC. [US/US]; 21 First Field Road Suite 200 Gaithersburg, Maryland 20878 (US) (For All Designated States Except US).
HILBERT, David M. [US/US]; (US) (For US Only)
Inventors: HILBERT, David M.; (US)
Agent: SHEA, JR., Timothy J.; Sterne, Kessler, Goldstein & Fox PLLC 1100 New York Avenue N.W. Washington, District of Columbia 20005 (US)
Priority Data:
61/442,106 11.02.2011 US
Title (EN) MONOVALENT AND MULTIVALENT MULTISPECIFIC COMPLEXES AND USES THEREOF
(FR) COMPLEXES PLURISPÉCIFIQUES MONOVALENTS ET MULTIVALENTS ET LEURS UTILISATIONS
Abstract: front page image
(EN)Monovalent and multivalent multispecific complexes including ELP-MRD fusion proteins containing one or more modular recognition domains (MRDs) that bind target antigens are described. The use of these monovalent and multivalent multispecific complexes (e.g., ELP- MRD fusion proteins) in diagnostic, prognostic, and therapeutic applications and methods of making these complexes are also described.
(FR)L'invention concerne des complexes plurispécifiques monovalents et multivalents qui comprennent des protéines hybrides ELP-MRD contenant un ou plusieurs domaines modulaires de reconnaissance (MRD) qui se lient à des antigènes cibles. L'invention concerne également l'utilisation de ces complexes plurispécifiques monovalents et multivalents (par exemple des protéines hybrides ELP-MRD) dans des applications de diagnostic, de pronostic et thérapeutiques, ainsi que des procédés de fabrication de ces complexes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)