WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012109534) CELLS AND METHODS FOR PRODUCING ISOBUTYRIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/109534    International Application No.:    PCT/US2012/024640
Publication Date: 16.08.2012 International Filing Date: 10.02.2012
IPC:
C12N 1/20 (2006.01), C12N 9/00 (2006.01), C12N 9/16 (2006.01), C12P 7/52 (2006.01)
Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA [US/US]; Office for Technology Commercialization 1000 Westgate Drive Suite 160 Saint Paul, Minnesota 55114-8658 (US) (For All Designated States Except US).
ZHANG, Kechun [CN/US]; (US) (For US Only).
XIONG, Mingyong [CN/US]; (US) (For US Only).
WOODRUFF, Adam P. [US/US]; (US) (For US Only)
Inventors: ZHANG, Kechun; (US).
XIONG, Mingyong; (US).
WOODRUFF, Adam P.; (US)
Agent: GRAM, Christophe D.; Mueting, Raasch & Gebhardt, P.A. P.O. Box 581336 Minneapolis, Minnesota 55458-1336 (US)
Priority Data:
61/441,939  11.02.2011 US
Title (EN) CELLS AND METHODS FOR PRODUCING ISOBUTYRIC ACID
(FR) CELLULES ET PROCÉDÉS DE PRODUCTION D'ACIDE ISOBUTYRIQUE
Abstract: front page image
(EN)Disclosed herein are cells and methods for renewably producing isobutyrate. In some cases, the cells can include a heterologous DNA that encodes at least one enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate. In other cases, the cells can include a genetically modified enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate to a degree greater than the wild-type version of the enzyme. In other cases, the cells can include one or more enzyme that catalyze the conversion of 2-ketovaline to isobutyrate. Generally, methods include growing the cells in a medium that includes a carbon source that the cells are able to convert to isobutyrate.
(FR)La présente invention concerne des cellules et des procédés de production d'isobutyrate de façon renouvelable. Dans certains cas, les cellules peuvent comprendre un ADN hétérologue qui code pour au moins une enzyme qui catalyse la conversion de l'isobutyraldéhyde en isobutyrate. Dans d'autres cas, les cellules peuvent comprendre une enzyme génétiquement modifiée qui catalyse la conversion de l'isobutyraldéhyde en isobutyrate à un degré supérieur à la version de type sauvage de l'enzyme. Dans d'autres cas, les cellules peuvent comprendre une ou plusieurs enzymes qui catalysent la conversion de la 2-cétovaline en isobutyrate. Généralement, l'invention concerne des procédés comprenant la croissance des cellules dans un milieu qui comprend une source de carbone que les cellules sont aptes à convertir en isobutyrate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)