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1. (WO2012109445) HYBRID OPIOID COMPOUNDS AND COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/109445    International Application No.:    PCT/US2012/024482
Publication Date: 16.08.2012 International Filing Date: 09.02.2012
IPC:
A61K 31/485 (2006.01), A61P 25/04 (2006.01)
Applicants: QRXPHARMA LTD. [AU/AU]; Level 1, 194 Miller Street North Sydney, NSW 2060 (AU) (For All Designated States Except US).
HOLADAY, John, W. [US/US]; (US) (For US Only).
MAGISTRO, Philip [US/US]; (US) (For US Only)
Inventors: HOLADAY, John, W.; (US).
MAGISTRO, Philip; (US)
Agent: HAUG, Edgar H; FROMMER LAWRENCE & HAUG LLP 745 Fifth Avenue New York, NY 10151 (US)
Priority Data:
13/024,298 09.02.2011 US
Title (EN) HYBRID OPIOID COMPOUNDS AND COMPOSITIONS
(FR) COMPOSÉS OPIOÏDES HYBRIDES ET COMPOSITIONS LES COMPORTANT
Abstract: front page image
(EN)Disclosed are hybrid opioid compounds, mixed opioid salts, compositions comprising the hybrid opioid compounds and mixed opioid salts, and methods of use thereof. More particularly, in one aspect the hybrid opioid compound includes at least two opioid compounds that are covalently bonded to a linker moiety. In another aspect, the hybrid opioid compound relates to mixed opioid salts comprising at least two different opioid compounds or an opioid compound and a different active agent Also disclosed are pharmaceutical compositions, as well as to methods of treating pain in humans using the hybrid compounds and mixed opioid salts.
(FR)L'invention concerne des composés opioïdes hybrides, des sels opioïdes mixtes, des compositions comportant les composés opioïdes hybrides et sels opioïdes mixtes, et leurs procédés d'utilisation. Plus particulièrement, sous un aspect, le composé opioïde hybride comprend au moins deux composés opioïdes qui sont liés de manière covalente à une fraction liante. Sous un autre aspect, le composé opioïde hybride concerne des sels opioïdes mixtes comportant au moins deux composés opioïdes différents ou un composé opioïde et un agent actif différent. L'invention concerne également des compositions pharmaceutiques, ainsi que des méthodes de traitement de la douleur chez les êtres humains à l'aide des composés hybrides et des sels opioïdes mixtes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)