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1. (WO2012109406) METHODS FOR TREATING PULMONARY HYPERTENSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/109406    International Application No.:    PCT/US2012/024411
Publication Date: 16.08.2012 International Filing Date: 09.02.2012
IPC:
A61K 31/522 (2006.01), A61P 9/08 (2006.01), A61P 9/12 (2006.01)
Applicants: THE MEDICINES COMPANY [US/US]; 8 Sylvan Way Parsippany, NJ 07054 (US) (For All Designated States Except US).
KYLHAMMAR, David [SE/SE]; (SE) (For US Only).
RÅDEGRAN, Göran [SE/SE]; (SE) (For US Only)
Inventors: KYLHAMMAR, David; (SE).
RÅDEGRAN, Göran; (SE)
Agent: PRESTIA, Paul, F.; RatnerPrestia P.O. Box 980 Valley Forge, PA 19482 (US)
Priority Data:
61/441,081 09.02.2011 US
Title (EN) METHODS FOR TREATING PULMONARY HYPERTENSION
(FR) MÉTHODES DE TRAITEMENT DE L'HYPERTENSION PULMONAIRE
Abstract: front page image
(EN)The present invention relates to methods for treating or preventing pulmonary hypertension, reducing mortality in a subject experiencing pulmonary hypertension, or inhibiting ADP-mediated vasoconstriction of pulmonary arteries in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a reversible P2Yi2 receptor antagonist. Also provided are related medicaments, pharmaceutical compositions, and methods for preparing the medicaments.
(FR)La présente invention concerne des méthodes de traitement et de prévention de l'hypertension pulmonaire, de réduction de la mortalité chez un sujet souffrant d'hypertension pulmonaire, ou d'inhibition de la vasoconstriction des artères pulmonaires médiée par l'ADP chez un sujet. Lesdites méthodes comprennent l'administration audit sujet d'une quantité efficace d'une composition pharmaceutique comportant un antagoniste du récepteur P2Yi2 réversible. L'invention porte en outre sur des médicaments afférents, sur des compositions pharmaceutiques, et sur des procédés de préparation desdits médicaments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)