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Pub. No.:    WO/2012/109280    International Application No.:    PCT/US2012/024195
Publication Date: 16.08.2012 International Filing Date: 07.02.2012
C12P 21/08 (2006.01), A61K 39/395 (2006.01), G01N 33/00 (2006.01)
Applicants: NEOTOPE BIOSCIENCES LIMITED [IE/IE]; Treasury Building Lower Grand Canal Street 2 Dublin (IE) (For All Designated States Except US).
SCHENK, Dale, B. [US/US]; (US) (For US Only).
NIJJAR, Tarlochan, S. [US/US]; (US) (For US Only).
PAYNE, Philip, W. [US/US]; (US) (For US Only).
BARBOUR, Robin [US/US]; (US) (For US Only)
Inventors: SCHENK, Dale, B.; (US).
NIJJAR, Tarlochan, S.; (US).
PAYNE, Philip, W.; (US).
BARBOUR, Robin; (US)
Agent: CHEN, ShengFeng; Alston & Bird LLP Bank of America Plaza 101 South Tryon Street Suite 4000 Charlotte, NC 28280-4000 (US)
Priority Data:
61/440,284 07.02.2011 US
Abstract: front page image
(EN)The disclosure provides antibodies that preferentially bind to an ApoE(1-272) fragment relative to ApoE(1-299). Further disclosed are humanized monoclonal antibody comprising three light chain Kabat CDRs and three heavy chain Kabat CDRs with framwork modifications. These antibodies serve to reduce the toxicity of this fragment and find use in treatment and prophylaxis of a variety of neurological diseases.
(FR)La présente invention concerne des anticorps qui se lient préférentiellement à un fragment ApoE(1-272) par rapport à ApoE(1-299). Ces anticorps servent à réduire la toxicité de ce fragment et ont une utilité dans le traitement et la prophylaxie d'une variété de maladies neurologiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)