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1. (WO2012109157) BIOPROBES AND METHODS OF USE THEREOF

Pub. No.:    WO/2012/109157    International Application No.:    PCT/US2012/024015
Publication Date: Aug 16, 2012 International Filing Date: Feb 6, 2012
IPC: C12Q 1/68
C07H 21/04
G01N 33/50
Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
KELLEY, Shana, O.
FANG, Zhichao
VASILYEVA, Elizaveta
Inventors: KELLEY, Shana, O.
FANG, Zhichao
VASILYEVA, Elizaveta
Title: BIOPROBES AND METHODS OF USE THEREOF
Abstract:
Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.