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1. WO2012108677 - NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Publication Number WO/2012/108677
Publication Date 16.08.2012
International Application No. PCT/KR2012/000899
International Filing Date 08.02.2012
IPC
C07D 277/34 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34Oxygen atoms
CPC
A61K 8/49
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 8/4913
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4906with one nitrogen as the only hetero atom
4913having five membered rings, e.g. pyrrolidone carboxylic acid
A61K 8/4946
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
494with more than one nitrogen as the only hetero atom
4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
A61K 8/4953
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
494with more than one nitrogen as the only hetero atom
4953containing pyrimidine ring derivatives, e.g. minoxidil
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
Applicants
  • 부산대학교 산학협력단 PUSAN NATIONAL UNIVERSITY INDUSTRYUNIVERSITY [KR]/[KR] (AllExceptUS)
  • 정해영 CHUNG, Hae-Young [KR]/[KR] (UsOnly)
  • 문형룡 MOON, Hyung-Ryong [KR]/[KR] (UsOnly)
  • 박민희 PARK, Min-Hi [KR]/[KR] (UsOnly)
  • 하영미 HA, Young-Mi [KR]/[KR] (UsOnly)
  • 박윤정 PARK, Yun-Jung [KR]/[KR] (UsOnly)
  • 박지영 PARK, Ji-Young [KR]/[KR] (UsOnly)
  • 김진아 KIM, Jin-Ah [KR]/[KR] (UsOnly)
  • 이지연 LEE, Ji-Yeon [KR]/[KR] (UsOnly)
  • 이경진 LEE, Kyung-Jin [KR]/[KR] (UsOnly)
Inventors
  • 정해영 CHUNG, Hae-Young
  • 문형룡 MOON, Hyung-Ryong
  • 박민희 PARK, Min-Hi
  • 하영미 HA, Young-Mi
  • 박윤정 PARK, Yun-Jung
  • 박지영 PARK, Ji-Young
  • 김진아 KIM, Jin-Ah
  • 이지연 LEE, Ji-Yeon
  • 이경진 LEE, Kyung-Jin
Agents
  • 특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2011-001154309.02.2011KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR
(FR) NOUVEAU COMPOSÉ À ACTIVITÉS DE BLANCHIMENT DE LA PEAU, ANTI-OXYDANTE POUR LA PEAU ET PPAR ET UTILISATION MÉDICALE CORRESPONDANTE
(KO) 피부미백, 항산화 및 PPAR 활성을 갖는 신규 화합물 및 이의 의학적 용도
Abstract
(EN) The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARα and PPARγ activity.
(FR) La présente invention concerne un nouveau composé à activités de blanchiment de la peau, anti-oxydante pour la peau et PPAR et son utilisation médicale. Selon l'invention, ces composés peuvent être utilisés de manière avantageuse dans des compositions pharmaceutiques ou des produits cosmétiques de blanchiment du fait de leur activité de blanchiment de la peau par inhibition de la tyrosinase, et dans la prévention ou le traitement du vieillissement de la peau ou analogue du fait de leur activité anti-oxydante, et dans des compositions pharmaceutiques ou des aliments naturels utiles dans la prévention et le traitement de l'obésité, de maladies métabolique ou cardiovasculaire du fait de leur activité PPAR et, plus particulièrement, PPARα et PPARγ.
(KO) 본 발명은 피부미백, 항산화 및 PPAR 활성을 갖는 신규 화합물 및 이의 의학적 용도에 관한 것으로, 본 발명에 따른 화합물들은 티로시나아제를 억제하는 피부미백 활성을 지니므로 피부미백용 약학조성물 또는 화장품에 유용하게 사용될 수 있고, 항산화 활성을 지니므로 피부노화 등의 예방 또는 치료에 유용하게 사용될 수 있으며, 또한 PPAR 활성 특히, PPARα 및 PPARγ 활성을 지니므로 비만, 대사성 질환 또는 심혈관계 질환을 예방하고 치료하는 데에 유용한 약학조성물 또는 건강식품으로 사용될 수 있다.
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