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1. (WO2012108586) METHOD FOR PRODUCING LYMPHOCYTES INCLUDING ACTIVATED NATURAL KILLER CELLS, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/108586    International Application No.:    PCT/KR2011/003331
Publication Date: 16.08.2012 International Filing Date: 04.05.2011
IPC:
C12N 5/0783 (2010.01), C07K 16/18 (2006.01), A61K 35/26 (2006.01), A61P 35/00 (2006.01)
Applicants: CHABIO&DIOSTECH CO., LTD. [KR/KR]; 151-21, Buk-ri, Namsa-myeon, Cheoin-gu, Yongin-city Kyunggi-do 449-884 (KR) (For All Designated States Except US).
LIM, Dae-Seog [KR/KR]; (KR) (For US Only).
HEO, Seong-Beom [KR/KR]; (KR) (For US Only).
KIM, Hye-Sun [KR/KR]; (KR) (For US Only).
HAN, Kye-Beom [KR/KR]; (KR) (For US Only).
CHUNG, Hyung-Min [KR/KR]; (KR) (For US Only)
Inventors: LIM, Dae-Seog; (KR).
HEO, Seong-Beom; (KR).
KIM, Hye-Sun; (KR).
HAN, Kye-Beom; (KR).
CHUNG, Hyung-Min; (KR)
Agent: OH, Kook-Jin; 302, Dooeon Bldg., 1708-6, Seocho-dong, Seocho-gu Seoul 137-884 (KR)
Priority Data:
10-2011-0010942 08.02.2011 KR
Title (EN) METHOD FOR PRODUCING LYMPHOCYTES INCLUDING ACTIVATED NATURAL KILLER CELLS, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME
(FR) PROCÉDÉ POUR PRODUIRE DES LYMPHOCYTES COMPRENANT DES CELLULES TUEUSES NATURELLES ACTIVÉES, ET COMPOSITION PHARMACEUTIQUE COMPRENANT CEUX-CI
(KO) 활성화된 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물
Abstract: front page image
(EN)The present invention relates to a method for producing lymphocytes including NK cells, the capability of producing interferon-γ of which is significantly enhanced, by culturing mononuclear cells in the presence of gamma globulin. In particular, the present invention relates to a method for producing lymphocytes including activated natural killer cells for targeting cancer cells that express HER2/neu antigen such as breast cancer and ovarian cancer, by binding an anti-HER2/neu antibody to a lymphocyte having activated natural killer cells, and also relates to a pharmaceutical composition including same.
(FR)La présente invention concerne un procédé pour produire des lymphocytes comprenant des cellules NK, dont la capacité de production d'interféron γ est significativement augmentée, par culture de cellules mononucléaires en présence de gamma-globuline. En particulier, la présente invention concerne un procédé pour produire des lymphocytes comprenant des cellules tueuses naturelles activées pour cibler des cellules cancéreuses qui expriment un antigène HER2/neu tel que le cancer du sein et le cancer ovarien, par liaison d'un anticorps anti-HER2/neu à un lymphocyte comprenant des cellules tueuses naturelles activées, et concerne en outre une composition pharmaceutique comprenant ceux-ci.
(KO)본 발명은 감마글로불린 존재하에서 단핵구 세포를 배양함으로써 인터페론-γ 생성능이 현저하게 증가된 NK 세포를 포함하는 림프구의 제조방법을 제공한다. 또한, 본 발명은 활성화된 자연살해 세포를 포함하는 림프구에 항-HER2/neu 항체를 결합시킴으로써, 유방암, 난소암 등의 HER2/neu 항원을 발현하는 암세포로의 표적지향을 위한 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 암세포 표적지향을 위한 약학 조성물을 제공한다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)