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1. (WO2012108489) AQUEOUS COMPOSITION HAVING IMPROVED HYDROPHILIC DRUG PENETRABILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/108489    International Application No.:    PCT/JP2012/052932
Publication Date: 16.08.2012 International Filing Date: 09.02.2012
IPC:
A61K 47/18 (2006.01), A61K 9/08 (2006.01), A61K 31/7076 (2006.01), A61K 47/10 (2006.01), A61P 27/02 (2006.01), A61P 27/06 (2006.01)
Applicants: SANTEN PHARMACEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Osaka-shi, Osaka 5338651 (JP) (For All Designated States Except US).
INAGAKI, Koji [JP/JP]; (JP) (For US Only).
HORIBE, Yoshihide [JP/JP]; (JP) (For US Only).
NAKADA, Yuichiro [JP/JP]; (JP) (For US Only)
Inventors: INAGAKI, Koji; (JP).
HORIBE, Yoshihide; (JP).
NAKADA, Yuichiro; (JP)
Agent: Fukami Patent Office, p.c.; Nakanoshima Central Tower, 2-7, Nakanoshima 2-chome, Kita-ku, Osaka-shi, Osaka 5300005 (JP)
Priority Data:
2011-027431 10.02.2011 JP
Title (EN) AQUEOUS COMPOSITION HAVING IMPROVED HYDROPHILIC DRUG PENETRABILITY
(FR) COMPOSITION AQUEUSE PRÉSENTANT UNE MEILLEURE PÉNÉTRABILITÉ DES MÉDICAMENTS HYDROPHILES
(JA) 親水性薬物の薬物移行性を改善した水性組成物
Abstract: front page image
(EN)Provided is an aqueous composition containing a hydrophilic drug, wherein in order to improve the penetrability of the drug into the site of action of the drug so that a desired effect is exhibited at a low dose and safety when using the drug is improved, the aqueous composition contains the hydrophilic drug and a benzalkonium halide and has an osmotic pressure ratio of 0.5 or less. The aqueous composition preferably further contains a polyhydric alcohol. Further, the benzalkonium halide is preferably benzalkonium chloride.
(FR)La présente invention concerne une composition aqueuse contenant un médicament hydrophile, la composition aqueuse contenant le médicament hydrophile et un halogénure de benzalkonium et ayant un rapport de pression osmotique inférieur ou égal à 0,5 en vue d'améliorer la pénétrabilité du médicament au site d'action du médicament, d'obtenir un effet souhaité à une faible dose et d'améliorer la sécurité lors de l'utilisation du médicament. La composition aqueuse contient de préférence un alcool polyhydrique. En outre, l'halogénure de benzalkonium est de préférence un chlorure de benzalkonium.
(JA) 親水性薬物を含有する水性組成物において、該薬物の薬物作用部位への移行性を改善し、低用量で所望の薬効を発現させ、薬剤使用時の安全性を向上させるために、親水性薬物およびベンザルコニウムハロゲン化物を含有し、浸透圧比が0.5以下である水性組成物が提供される。当該水性組成物は、多価アルコールをさらに含有することが好ましく、また、ベンザルコニウムハロゲン化物はベンザルコニウム塩化物であることが好ましい。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)