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1. (WO2012107934) FLINDEROLE ANALOGUES AND PROCESS FOR SYNTHESIS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/107934    International Application No.:    PCT/IN2011/000899
Publication Date: 16.08.2012 International Filing Date: 28.12.2011
IPC:
C07D 487/04 (2006.01)
Applicants: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH [IN/IN]; Anusandhan Bhawan, Rafi Marg New Delhi - 110001 (IN) (For All Designated States Except US).
DETHE, Dattatraya, Hanumant [IN/IN]; (IN) (For US Only).
ERANDE, Rohan, Diliprao [IN/IN]; (IN) (For US Only).
RANJAN, Alok [IN/IN]; (IN) (For US Only)
Inventors: DETHE, Dattatraya, Hanumant; (IN).
ERANDE, Rohan, Diliprao; (IN).
RANJAN, Alok; (IN)
Agent: DHAWAN, Ramesh, C.; Lall Lahiri & Salhotra Plot No. B -28, Sector - 32 Institutional Area Gurgaon 122 001 Haryana (IN)
Priority Data:
0336/DEL/2011 10.02.2011 IN
Title (EN) FLINDEROLE ANALOGUES AND PROCESS FOR SYNTHESIS THEREOF
(FR) ANALOGUES DE FLINDEROLE ET LEUR PROCÉDÉ DE SYNTHÈSE
Abstract: front page image
(EN)The present invention discloses flinderole compounds/analogues of formula I and to a process for the preparation of same, comprising stereo- and regioselective [3+2] cycloaddition reaction of a tertiary alcohol (1a') and a sulphonated diene (1b') in presence of Lewis acid selected from Cu(OTf)2 or BF3OEt2 and a non-polar solvent at room temperature. The flinderole compounds /analogues of the instant invention and prepared by the process described therein is represented by the general formula I,(The formula I should be inserted here) wherein R1-R4 are described herein in the specification.
(FR)La présente invention concerne des composés/analogues de flinderole de formule I et leur procédé de préparation, comprenant une réaction de cycloaddition stéréo- et régiosélective [3+2] d'un alcool tertiaire (1a') et d'un diène sulfoné (1b') en présence d'acide de Lewis choisi parmi Cu(OTf)2 ou BF3OEt2 et un solvant non polaire à la température ambiante. Les composés/analogues de flinderole selon la présente invention et préparés par le procédé selon l'invention sont représentés par la formule I, dans laquelle R1-R4 sont tels que définis dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)