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1. (WO2012107932) B CELL CLONAL IMMUNOTOXIN AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/107932    International Application No.:    PCT/IN2011/000258
Publication Date: 16.08.2012 International Filing Date: 18.04.2011
IPC:
C07K 19/00 (2006.01), C07K 14/155 (2006.01), C12N 1/21 (2006.01), C12N 15/62 (2006.01), C12N 15/63 (2006.01), A61K 38/16 (2006.01), A61P 31/18 (2006.01), A61P 37/06 (2006.01), G01N 33/53 (2006.01)
Applicants: TRANSGENE BIOTEK LTD. [IN/IN]; Plot 68, 69, 70 & 70a ANRICH Industrial Area IDA Bollaram, Medak District AP 502315 Medak District 502315 (IN) (For All Designated States Except US).
KOLLIPARA, Koteswara Rao [IN/IN]; (IN) (For US Only)
Inventors: KOLLIPARA, Koteswara Rao; (IN)
Agent: KEWALRAMANI, Nishant; No 40 1st Floor, 3rd Main Road JC Industrial Estate Kanakapura Road Bangalore 560062 (IN)
Priority Data:
402/CHE/2011 11.02.2011 IN
Title (EN) B CELL CLONAL IMMUNOTOXIN AND USE THEREOF
(FR) IMMUNOTOXINE CLONALE DE LYMPHOCYTE B ET SON UTILISATION
Abstract: front page image
(EN)Provided are fusion proteins having the amino acid sequences as shown in SEQ ID NO: 2, SEQ ID NO: 4 and SEQ ID NO: 6, genes encoding said fusion proteins, vectors comprising said genes and cell lines comprising said vectors. The fusion proteins can target and/or kill B cells displaying antibodies specific to gp120 to prevent HIV infection or AIDS progression in HIV infected persons. Also provided are pharmaceutical composition and diagnostic kit as well as anti-HIV application of the fusion proteins.
(FR)La présente invention concerne des protéines hybrides comprenant les séquences d'acides aminés telles que représentées dans SEQ ID NO: 2, SEQ ID NO: 4 et SEQ ID NO: 6, des gènes codant pour lesdites protéines hybrides, des vecteurs comportant lesdits gènes et des lignées cellulaires comportant lesdits vecteurs. Les protéines hybrides peuvent cibler et/ou tuer des lymphocytes B présentant des anticorps spécifiques contre gp120 pour prévenir une infection à VIH ou la progression du SIDA chez des personnes infectées par le VIH. L'invention concerne également une composition pharmaceutique et une trousse de diagnostic ainsi qu'une application anti-VIH des protéines hybrides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)