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1. (WO2012107579) HYDROPHOBIC MODIFIED PEPTIDES AND THEIR USE FOR LIVER SPECIFIC TARGETING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/107579    International Application No.:    PCT/EP2012/052349
Publication Date: 16.08.2012 International Filing Date: 10.02.2012
IPC:
A61K 49/00 (2006.01), A61K 49/08 (2006.01), A61K 51/08 (2006.01), C07K 14/005 (2006.01), A61K 47/48 (2006.01)
Applicants: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG [DE/DE]; Grabengasse 1 69117 Heidelberg (DE) (For All Designated States Except US).
MIER, Walter [DE/DE]; (DE) (For US Only).
URBAN, Stephan [DE/DE]; (DE) (For US Only).
MEHRLE, Stefan [DE/DE]; (DE) (For US Only).
HABERKORN, Uwe [DE/DE]; (DE) (For US Only)
Inventors: MIER, Walter; (DE).
URBAN, Stephan; (DE).
MEHRLE, Stefan; (DE).
HABERKORN, Uwe; (DE)
Agent: ZWICKER, Jörk; Dr. Volker Vossius Patentanwälte Partnerschaftsgesellschaft Radlkoferstrasse 2 81373 München (DE)
Priority Data:
61/441,492 10.02.2011 US
Title (EN) HYDROPHOBIC MODIFIED PEPTIDES AND THEIR USE FOR LIVER SPECIFIC TARGETING
(FR) PEPTIDES MODIFIÉS HYDROPHOBES ET LEUR UTILISATION POUR UN CIBLAGE HÉPATIQUE SPÉCIFIQUE
Abstract: front page image
(EN)The present invention relates to hydrophobic modified peptides for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to the use of the inventive hydrophobic modified peptides as well as to a method for the prevention and/or treatment of liver diseases or disorders.
(FR)La présente invention concerne des peptides modifiés hydrophobes pour l'apport spécifique de composés au foie, de préférence aux hépatocytes, in vitro ainsi qu'in vivo. La présente invention concerne des compositions pharmaceutiques comprenant ledit ou lesdits peptides modifiés hydrophobes et le ou les composés devant être apportés spécifiquement au foie. La présente invention concerne en outre l'utilisation des peptides modifiés hydrophobes de l'invention ainsi qu'un procédé pour la prévention et/ou le traitement de maladies ou de troubles hépatiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)