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1. (WO2012107500) [1, 2, 4] TRIAZOLO [4, 3 -B] PYRIDAZINE COMPOUNDS AS INHIBITORS OF THE C-MET TYROSINE KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/107500    International Application No.:    PCT/EP2012/052147
Publication Date: 16.08.2012 International Filing Date: 08.02.2012
IPC:
C07D 487/04 (2006.01), A61K 31/5025 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (For All Designated States Except US).
DENG, Haibing [CN/CN]; (CN) (For US Only).
FU, Xingnian [CN/CN]; (CN) (For US Only).
GUO, Haibing [CN/CN]; (CN) (For US Only).
HE, Feng [US/CN]; (CN) (For US Only).
MI, Yuan [CN/CN]; (CN) (For US Only).
YAN, Xiaoxia [CN/CN]; (CN) (For US Only).
YU, Hongping [CA/CN]; (CN) (For US Only).
ZHANG, Ji Yue (Jeff) [US/CN]; (CN) (For US Only)
Inventors: DENG, Haibing; (CN).
FU, Xingnian; (CN).
GUO, Haibing; (CN).
HE, Feng; (CN).
MI, Yuan; (CN).
YAN, Xiaoxia; (CN).
YU, Hongping; (CN).
ZHANG, Ji Yue (Jeff); (CN)
Agent: STRANG, Andrea; Novartis Pharma AG Patent Department CH-4002 Basel (CH)
Priority Data:
PCT/CN2011/070909 10.02.2011 CN
PCT/CN2011/083960 14.12.2011 CN
Title (EN) [1, 2, 4] TRIAZOLO [4, 3 -B] PYRIDAZINE COMPOUNDS AS INHIBITORS OF THE C-MET TYROSINE KINASE
(FR) COMPOSÉS DE [1, 2, 4] TRIAZOLO [4, 3 -B] PYRIDAZINE EN TANT QU'INHIBITEURS DE LA TYROSINE KINASE C-MET
Abstract: front page image
(EN)The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
(FR)La présente invention concerne des composés de formule (I) et leurs sels, les substituants dans la formule étant tels que définis dans la description ; un composé de formule (I) destiné à être utilisé dans le traitement du corps humain ou animal, en particulier concernant des maladies ou conditions liées à la tyrosine kinase c-Met ; l'utilisation d'un composé de formule (I) pour la fabrication d'un médicament pour le traitement de telles maladies ; des compositions pharmaceutiques comportant un composé de formule (I), éventuellement en présence d'un partenaire de combinaison, et des procédés pour la préparation d'un composé de formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)