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1. (WO2012107465) HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/107465    International Application No.:    PCT/EP2012/052090
Publication Date: 16.08.2012 International Filing Date: 08.02.2012
Chapter 2 Demand Filed:    06.12.2012    
IPC:
C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 403/14 (2006.01), C07D 405/14 (2006.01), C07D 471/04 (2006.01), C07D 473/16 (2006.01), C07D 473/32 (2006.01), C07D 473/34 (2006.01), C07D 473/40 (2006.01), C07D 487/04 (2006.01), C07D 495/04 (2006.01), C07D 498/06 (2006.01), C07D 513/02 (2006.01), C07D 519/00 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
HEALD, Robert [GB/GB]; (GB) (For US Only).
PRICE, Stephen [GB/GB]; (GB) (For US Only).
SAFINA, Brian [US/US]; (US) (For US Only).
SAVY, Pascal, Pierre, Alexandre [GB/GB]; (GB) (For US Only).
SEWARD, Eileen, M. [IE/GB]; (GB) (For US Only).
SUTHERLIN, Daniel, P. [US/US]; (US) (For US Only).
WASZKOWYCZ, Bohdan [GB/GB]; (GB) (For US Only)
Inventors: HEALD, Robert; (GB).
PRICE, Stephen; (GB).
SAFINA, Brian; (US).
SAVY, Pascal, Pierre, Alexandre; (GB).
SEWARD, Eileen, M.; (GB).
SUTHERLIN, Daniel, P.; (US).
WASZKOWYCZ, Bohdan; (GB)
Agent: SAUER, Frank; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
61/441,014 09.02.2011 US
Title (EN) HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE PI3 KINASE
Abstract: front page image
(EN)Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
(FR)L'invention concerne des composés de Formule I, notamment des stéréo-isomères, des isomères géométriques, des tautomères, des métabolites et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles pour l'inhibition de l'isoforme delta de PI3K, et pour le traitement de troubles à médiation par des lipides kinases, tels qu'une inflammation, des troubles immunologiques et le cancer. L'invention concerne également des procédés d'utilisation des composés de Formule I pour un diagnostic, une prévention ou un traitement in vitro, in situ et in vivo de tels troubles dans des cellules de mammifères, ou d'états pathologiques associés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)