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1. (WO2012107363) NOVEL COMPOSITION FOR THE TREATMENT OF CYSTIC FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/107363    International Application No.:    PCT/EP2012/051880
Publication Date: 16.08.2012 International Filing Date: 03.02.2012
IPC:
A61K 9/00 (2006.01), A61K 9/28 (2006.01), A61K 9/48 (2006.01), A61K 31/192 (2006.01), A61K 31/343 (2006.01), A61K 31/37 (2006.01), A61K 31/4015 (2006.01), A61K 31/404 (2006.01), A61K 31/4174 (2006.01), A61K 31/427 (2006.01), A61K 31/437 (2006.01), A61K 31/44 (2006.01), A61K 31/444 (2006.01), A61K 31/472 (2006.01), A61K 31/498 (2006.01)
Applicants: SCIPHARM SÀRL [LU/LU]; 33, rue Hiehl L-6131 Junglinster (LU) (For All Designated States Except US).
FREISSMUTH, Michael [AT/AT]; (AT) (For US Only).
GLOECKEL, Christina [AT/AT]; (AT) (For US Only).
KOENIG, Xaver [AT/AT]; (AT) (For US Only).
KEUERLEBER, Simon [DE/AT]; (AT) (For US Only)
Inventors: FREISSMUTH, Michael; (AT).
GLOECKEL, Christina; (AT).
KOENIG, Xaver; (AT).
KEUERLEBER, Simon; (AT)
Agent: LOIDL, Manuela; Donau-City-Strasse 1 A-1220 Vienna (AT)
Priority Data:
11153541.5 07.02.2011 EP
Title (EN) NOVEL COMPOSITION FOR THE TREATMENT OF CYSTIC FIBROSIS
(FR) NOUVELLE COMPOSITION POUR LE TRAITEMENT DE LA MUCOVISCIDOSE
Abstract: front page image
(EN)The present invention provides a composition comprising at least one prostacyclin or prostacyclin analogue or a pharmaceutically acceptable salt thereof and at least one phosphodiesterase (PDE) 4inhibitor and optionally a further PDE inhibitor for use in preventing or treating cystic fibrosis by selectively increasing the cAMP levels in bronchoepithelial cells.
(FR)L'invention concerne une composition contenant au moins une prostacycline ou un analogue de prostacycline ou un sel pharmaceutiquement acceptable de celle-ci et au moins un inhibiteur de phosphodiestérase 4 (PDE) et facultativement un autre inhibiteur de PDE. Cette composition est destinée à être utilisée dans la prévention ou le traitement de la mucoviscidose, cette composition ayant pour effet d'augmenter de façon sélective le taux d'AMPc dans les cellules broncho-épithéliales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)