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Pub. No.:    WO/2012/106713    International Application No.:    PCT/US2012/023985
Publication Date: 09.08.2012 International Filing Date: 06.02.2012
A61K 47/48 (2006.01), A61K 47/30 (2006.01), A61K 9/16 (2006.01), A61K 9/14 (2006.01), A61P 35/00 (2006.01)
Applicants: CASE WESTERN RESERVE UNIVERSITY [US/US]; 10900 Euclid Avenue Cleveland, OH 44106 (US) (For All Designated States Except US).
BASILION, James [US/US]; (US) (For US Only).
BURDA, Clemens [US/US]; (US) (For US Only)
Inventors: BASILION, James; (US).
BURDA, Clemens; (US)
Agent: SUTKUS, Richard, A.; Tarolli, Sundheim, Covell & Tummino, LLP 1300 East Ninth Street Suite 1700 Cleveland, OH 44114 (US)
Priority Data:
61/439,443 04.02.2011 US
Abstract: front page image
(EN)A composition for treating a disorder in a subject includes a polyethylene glycolylated (PEGylated) nanoparticle, at least one hydrophobic therapeutic agent coupled to the surface of the nanoparticle; and at least one targeting moiety coupled to polyethylene glycol of the nanoparticle for targeting the composition to a cell associated with disorder.
(FR)L'invention concerne une composition pour le traitement d'un trouble, chez un sujet, ladite composition comprenant une nanoparticule greffée par polyéthylène glycol (PEGylée), au moins un agent thérapeutique hydrophobe couplé à la surface de la nanoparticule ; au moins une fraction de ciblage couplée au polyéthylène glycol de la nanoparticule, pour le ciblage de la composition vers une cellule associée à un trouble.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)