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Machine translation
1. (WO2012106711) A METHOD FOR DETECTING CHROMOSOME STRUCTURE AND GENE EXPRESSION SIMULTANEOUSLY IN SINGLE CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/106711    International Application No.:    PCT/US2012/023974
Publication Date: 09.08.2012 International Filing Date: 06.02.2012
IPC:
C12Q 1/68 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; Center For Technology Transfer 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104-6283 (US) (For All Designated States Except US).
RAJ, Arjun [US/US]; (US) (For US Only).
LEVESQUE, Marshall, J. [US/US]; (US) (For US Only)
Inventors: RAJ, Arjun; (US).
LEVESQUE, Marshall, J.; (US)
Agent: ALLEN, Justin, C.; Riverside Law, LLP 300 Four Falls Corporate Center, Suite 710 300 Conshohocken State Road West Conshohocken, PA 19428 (US)
Priority Data:
61/439,623 04.02.2011 US
Title (EN) A METHOD FOR DETECTING CHROMOSOME STRUCTURE AND GENE EXPRESSION SIMULTANEOUSLY IN SINGLE CELLS
(FR) PROCÉDÉ DE DÉTECTION DE STRUCTURE CHROMOSOMIQUE ET D'EXPRESSION GÉNIQUE SIMULTANÉMENT DANS CELLULES INDIVIDUELLES
Abstract: front page image
(EN)The present invention relates to systems and methods for measuring chromosome structure and gene expression. In one embodiment, the present invention includes an assay for determining the spatial organization of gene expression in the nucleus. The present invention also includes a method based on fluorescence in situ hybridization (FISI-I) that simultaneously yields information on the physical position and expression of individual genes, By lighting up a large number of targets on a particular chromosome using a bar- coding scheme, the large scale structure of an entire chromosome can be determined.
(FR)La présente invention concerne des systèmes et des procédés de mesure d'une structure chromosomique et d'une expression génique. Dans un mode de réalisation, la présente invention comprend un dosage pour la détermination de l'organisation spatiale de l'expression génique dans le noyau. La présente invention comprend également un procédé qui se fonde sur une hybridation in situ à fluorescence (FISI-I) qui génère simultanément des informations sur la position physique et l'expression de gènes individuels. En allumant un grand nombre de cibles sur un chromosome particulier à l'aide d'un schéma de code-barres, la structure à grande échelle d'un chromosome entier peut être déterminée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)