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1. (WO2012106669) FOXC1 ANTIBODIES AND METHODS OF THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/106669    International Application No.:    PCT/US2012/023871
Publication Date: 09.08.2012 International Filing Date: 03.02.2012
IPC:
C12N 5/07 (2010.01), A61K 39/395 (2006.01), C07K 16/18 (2006.01)
Applicants: JOHN WAYNE CANCER INSTITUTE [US/US]; 2200 Santa Monica Blvd. Santa Monica, California 90404 (US) (For All Designated States Except US).
CUI, Xiaojiang [US/US]; (US) (For US Only)
Inventors: CUI, Xiaojiang; (US)
Agent: DUEPPEN, Lara, J.; Perkins Coie LLP P.O. Box 1208 Seattle, Washington 98111-1208 (US)
Priority Data:
61/439,825 04.02.2011 US
Title (EN) FOXC1 ANTIBODIES AND METHODS OF THEIR USE
(FR) ANTICORPS ANTI-FOXC1 ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)In one embodiment, an isolated antibody or functional fragment thereof which binds an antigenic peptide sequence of human FOXC1 is provided herein. Such antibodies or functional fragments may be used to diagnose, prognose or treat basal-like breast cancer. The antibody or functional fragment may be a monoclonal antibody produced by a hybridoma cell line. Thus, a hybridoma cell line that produces a FOXC1 monoclonal antibody which binds an antigenic peptide sequence of human FOXC1 as described above is also provided.
(FR)Dans un mode de réalisation, l'invention concerne un anticorps isolé ou un fragment fonctionnel de celui-ci, qui se lie à une séquence peptidique antigénique de FOXC1 humain. De tels anticorps ou fragments fonctionnels peuvent être utilisés pour diagnostiquer, pronostiquer ou traiter un cancer du sein de type basal. L'anticorps ou le fragment fonctionnel peut être un anticorps monoclonal produit par une lignée de cellules d'hybridome. Ainsi, l'invention concerne également une lignée de cellules d'hybridome qui produit un anticorps monoclonal anti-FOXC1 qui se lie à une séquence peptidique antigénique de FOXC1 humain, tel que décrit ci-dessus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)