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1. (WO2012106578) HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/106578    International Application No.:    PCT/US2012/023737
Publication Date: 09.08.2012 International Filing Date: 03.02.2012
IPC:
C07K 16/10 (2006.01), A61K 39/42 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Blvd., Suite 325 MSC 7660 Bethesda, MD 20892-7660 (US) (For All Designated States Except US).
BRIGHAM AND WOMEN'S HOSPITAL [US/US]; 75 Francis Street Boston, MA 02115 (US) (For All Designated States Except US).
NABEL, Gary, J. [US/US]; (US) (For US Only).
KO, Sung-Youl [KR/US]; (US) (For US Only).
YANG, Zhi-Yong [US/US]; (US) (For US Only).
BLUMBERG, Richard [US/US]; (US) (For US Only)
Inventors: NABEL, Gary, J.; (US).
KO, Sung-Youl; (US).
YANG, Zhi-Yong; (US).
BLUMBERG, Richard; (US)
Agent: RYBAK, Sheree, Lynn; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204 (US)
Priority Data:
61/439,678 04.02.2011 US
Title (EN) HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc)
(FR) ANTICORPS NEUTRALISANT LE VIH, PRÉSENTANT DES MUTATIONS DANS LE DOMAINE CONSTANT (FC)
Abstract: front page image
(EN)IgG antibodies having one or more mutations in the Fc domain are disclosed. Monoclonal neutralizing antibodies having one or more mutations in the constant domain are disclosed that specifically bind to the CD4 binding site of HIV-1 gpl20. In some examples, such antibodies have a longer half-life than the corresponding native antibodies. The use of these antibodies to diagnose HIV infection or treat an HIV infection are also disclosed.
(FR)L'invention concerne des anticorps IgG présentant une ou plusieurs mutations dans le domaine Fc. L'invention concerne des anticorps monoclonaux neutralisants présentant une ou plusieurs mutations dans le domaine constant, qui se lient spécifiquement au site de liaison à CD4 de gpl20 de HIV-1. Dans certains exemples, de tels anticorps ont une demi-vie plus longue que les anticorps natifs correspondants. L'invention concerne également l'utilisation de ces anticorps pour diagnostiquer une infection par le VIH ou traiter une infection par le VIH. 10-8
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)