WO2012106525 DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION

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Publication Number WO/2012/106525

Publication Date 09.08.2012

International Application No. PCT/US2012/023646

International Filing Date 02.02.2012

IPC

CPC

Applicants

EXACT SCIENCES CORPORATION [US]/[US] (AllExceptUS)
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US]/[US] (AllExceptUS)
AHLQUIST, David A. [US]/[US] (UsOnly)
TAYLOR, William R. [US]/[US] (UsOnly)
ZOU, Hongzhi [CN]/[US] (UsOnly)
LIDGARD, Graham P. [US]/[US] (UsOnly)

Inventors

AHLQUIST, David A.
TAYLOR, William R.
ZOU, Hongzhi
LIDGARD, Graham P.

Agents

BROW, Mary Ann D.

Priority Data

61/438,649

02.02.2011

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION

(FR) ANALYSE NUMÉRIQUE DE SÉQUENCE DE MÉTHYLATION DE L'ADN

Abstract

(EN) The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

(FR) La présente invention concerne des procédés et des compositions pour la détermination, et l'utilisation de motifs spécifiques de méthylation indicateurs d'un adénome et d'un carcinome. En particulier, l'invention concerne l'analyse de loci CpG définis qui sont méthylés de manière coordonnée dans des ADN provenant d'échantillons cancéreux et d'adénome, des procédés d'identification de loci méthylés de façon coordonnée, et des procédés d'utilisation de l'analyse de loci méthylés de façon coordonnée dans une ou plusieurs régions marqueur dans la conception de dosages pour un adénome et un cancer.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68	involving nucleic acids
6813	Hybridisation assays
6827	for detection of mutation or polymorphism

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68	involving nucleic acids
6844	Nucleic acid amplification reactions
6858	Allele-specific amplification

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68	involving nucleic acids
6876	Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883	for diseases caused by alterations of genetic material
6886	for cancer

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1. WO2012106525 - DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION