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1. (WO2012106404) DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISORDERS THROUGH VIPR2 AND VPAC2R
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/106404    International Application No.:    PCT/US2012/023445
Publication Date: 09.08.2012 International Filing Date: 01.02.2012
IPC:
A61K 48/00 (2006.01), A61K 31/7105 (2006.01), A61K 31/7088 (2006.01), A61P 25/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 5th Floor Oakland, CA 94607-5200 (US) (For All Designated States Except US).
SEBAT, Janathan [US/US]; (US) (For US Only)
Inventors: SEBAT, Janathan; (US)
Agent: WARREN, Daniel, J.; Sutherland Asbill & Brennan LLP 999 Peachtree Street, NE Atlanta, GA 30309 (US)
Priority Data:
61/438,453 01.02.2011 US
Title (EN) DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISORDERS THROUGH VIPR2 AND VPAC2R
(FR) DIAGNOSTIC ET TRAITEMENT DE TROUBLES NEUROLOGIQUES PAR VIPR2 ET VPAC2R
Abstract: front page image
(EN)This invention provides diagnostic and therapeutic compositions and methods to detect and treat neurological disorders, such as schizophrenia, autism, and other related disorders through modulating vasointestinal peptide receptor 2 gene (VIPR2) expression or correcting pathogenic mutations of the VIPR2 gene, and through modulating the VIPR2 encoding vasointestinal peptide 2 receptor (VPAC2R) activity in the cycHc-AMP signaling with selective VPAC2R agonists, VPAC2R antagonists, and VIP or peptide derivatives or analogs thereof.
(FR)Cette invention concerne des compositions diagnostiques et thérapeutiques et des procédés de détection et de traitement de troubles neurologiques, comme la schizophrénie, l'autisme et d'autres troubles associés par la modulation de l'expression du gène de récepteur de peptide vasoactif intestinal 2 (VIPR2) ou la correction de mutations pathogènes du gène VIPR2, et par la modulation de l'activité du VIPR2 codant le récepteur de peptide vasoactif intestinal 2 (VPAC2R) dans la signalisation de cycHc-AMP avec des agonistes de VPAC2R sélectifs, des antagonistes de VPAC2R, et VIP ou ses dérivés ou analogues peptidiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)