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1. WO2012106382 - AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF

Publication Number WO/2012/106382
Publication Date 09.08.2012
International Application No. PCT/US2012/023406
International Filing Date 31.01.2012
IPC
A01N 43/40 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
34having rings with one nitrogen atom as the only ring hetero atom
40six-membered rings
A61K 9/72 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
72for smoking or inhaling
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
CPC
A61K 31/4418
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4418having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
A61K 9/0078
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0078for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
A61M 15/009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
009using medicine packages with incorporated spraying means, e.g. aerosol cans
A61M 2202/064
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2202Special media to be introduced, removed or treated
06Solids
064Powder
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • GENOA PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • SURBER, Mark, William [US]/[US] (UsOnly)
Inventors
  • SURBER, Mark, William
Agents
  • MUNSON, Peter, R.
Priority Data
61/438,20331.01.2011US
61/508,54215.07.2011US
61/559,67014.11.2011US
61/584,11906.01.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS ANALOGUES DE PYRIDONE ET DE PIRFÉNIDONE EN AÉROSOL, ET LEURS UTILISATIONS
Abstract
(EN)
Formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. Pirfenidone or pyridone analog compound formulations and delivery options allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include formulations, kits, and devices. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.
(FR)
La présente invention concerne des formulations de composés analogues de pyridone ou de pirfénidone pour aérosolisation, et l'utilisation de ces formulations pour permettre l'administration par aérosol de composés analogues de pyridone ou de pirfénidone pour prévenir ou traiter diverses maladies fibrotiques et inflammatoires, notamment des maladies associées au poumon, au cœur, au rein, au foie, à l'œil et au système nerveux central. Les formulations de composés analogues de pyridone ou de pirfénidone et les options d'administration permettent une administration locale efficace de composé analogue de pyridone ou de pirfénidone. Les compositions de l'invention comprennent des formulations, des kits et des dispositifs. Les procédés de l'invention comprennent des procédés d'inhalation, des indications et des procédés de fabrication pour la production et l'utilisation des compositions décrites.
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