Search International and National Patent Collections

1. (WO2012106264) TREATMENT AND PREVENTION OF BACTERIAL VAGINOSIS AND GARDNERELLA VAGINALIS INFECTIONS

Pub. No.:    WO/2012/106264    International Application No.:    PCT/US2012/023185
Publication Date: Aug 9, 2012 International Filing Date: Jan 30, 2012
IPC: A61K 38/46
A61P 31/04
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
RATNER, Adam J.
HYMES, Saul
Inventors: RATNER, Adam J.
HYMES, Saul
Title: TREATMENT AND PREVENTION OF BACTERIAL VAGINOSIS AND GARDNERELLA VAGINALIS INFECTIONS
Abstract:
G. vaginalis infection, a major cause of bacterial vaginosis (BV), is associated with biofilm formation. The present invention relates to treatment of G. vaginalis infections and BV with DNase. DNase reduces biofilm formation and increases biofilm breakdown, both in a dose dependent manner. The present invention further relates to treating BV and G. vaginalis infections with a combination of DNase and an antibiotic known to treat these diseases.