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1. (WO2012106188) C-28 AMINES OF C-3 MODIFIED BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/106188    International Application No.:    PCT/US2012/022847
Publication Date: 09.08.2012 International Filing Date: 27.01.2012
IPC:
C07J 63/00 (2006.01), A61K 31/56 (2006.01), A61P 31/18 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000 Route 206 and ProvinceLine Road Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
REGUEIRO-REN, Alicia [ES/US]; (US) (For US Only).
SWIDORSKI, Jacob [US/US]; (US) (For US Only).
SIT, Sing-Yuen [US/US]; (US) (For US Only).
CHEN, Yan [US/US]; (US) (For US Only).
CHEN, Jie [CN/US]; (US) (For US Only).
MEANWELL, Nicholas A. [US/US]; (US) (For US Only).
LIU, Zheng [US/US]; (US) (For US Only)
Inventors: REGUEIRO-REN, Alicia; (US).
SWIDORSKI, Jacob; (US).
SIT, Sing-Yuen; (US).
CHEN, Yan; (US).
CHEN, Jie; (US).
MEANWELL, Nicholas A.; (US).
LIU, Zheng; (US)
Agent: LEVIS, John F.; Bristol-Myers Squibb Company P.O. Box 4000 Princeton, New Jersey 08543-4000 (US)
Priority Data:
61/437,870 31.01.2011 US
Title (EN) C-28 AMINES OF C-3 MODIFIED BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS
(FR) AMINES EN C28 DE DÉRIVÉS D'ACIDE BÉTULINIQUE MODIFIÉ EN C-3 EN TANT QU'INHIBITEURS DE MATURATION DU VIH
Abstract: front page image
(EN)Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof: a compound of formula (I), a compound of formula (II), and a compound of formula (III).
(FR)L'invention concerne des composés ayant des propriétés médicamenteuses et biologiques, leurs compositions pharmaceutiques et leurs procédés d'utilisation. En particulier, l'invention concerne des amines en C-28 de dérivés d'acide bétulinique modifiés en C-3 qui possèdent une activité antivirale unique, en tant qu'inhibiteurs de maturation du VIH. Ces composés sont utiles pour le traitement du VIH et du SIDA. En particulier, la présente invention concerne les composés suivants, comprenant des sels de qualité pharmaceutique de ceux-ci : un composé de la formule (I), un composé de la formule (II) et un composé de la formule (III).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)