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1. (WO2012105801) NANOPARTICLE COATED WITH LIGAND INTRODUCED WITH LONG HYDROPHOBIC CHAIN AND METHOD FOR PREPARING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/105801    International Application No.:    PCT/KR2012/000749
Publication Date: 09.08.2012 International Filing Date: 31.01.2012
IPC:
B82B 1/00 (2006.01)
Applicants: SNU R&DB FOUNDATION [KR/KR]; San 56-1 Sillim-dong Gwanak-gu Seoul 151-742 (KR) (For All Designated States Except US).
JEONG, Jae Min [KR/KR]; (KR) (For US Only).
LEE, Young Kyoung [KR/KR]; (KR) (For US Only).
LEE, Dong Soo [KR/KR]; (KR) (For US Only).
CHUNG, June-Key [KR/KR]; (KR) (For US Only).
LEE, Myung Chul [KR/KR]; (KR) (For US Only)
Inventors: JEONG, Jae Min; (KR).
LEE, Young Kyoung; (KR).
LEE, Dong Soo; (KR).
CHUNG, June-Key; (KR).
LEE, Myung Chul; (KR)
Agent: LEE, Won Hee; 8th Fl. Sung-ji Heights II 642-16, Yoksam-dong Kangnam-ku Seoul 135-080 (KR)
Priority Data:
10-2011-0010203 01.02.2011 KR
Title (EN) NANOPARTICLE COATED WITH LIGAND INTRODUCED WITH LONG HYDROPHOBIC CHAIN AND METHOD FOR PREPARING SAME
(FR) NANOPARTICULE REVÊTUE D'UN LIGAND INTRODUIT AVEC UNE CHAÎNE HYDROPHOBE LONGUE ET SON PROCÉDÉ DE PRÉPARATION
(KO) 긴 소수성 사슬이 도입된 리간드로 코팅된 나노입자 및 이의 제조방법
Abstract: front page image
(EN)The present invention relates to a nanoparticle having a linker connected to a long alkane or alkene chain, and a method for preparing the nanoparticle. The alkyl chain of C10~30 introduced with a ligand of the present invention can be coated on a hydrophobic nanoparticle through a noncovalent bond, enabling easy introduction of various ligands to the nanoparticle, and the nanoparticle having various functional groups prepared using the method can be applied to fluorescent detection, MRI, raman spectroscopy, optical detection, PET, SPECT, or gamma image device, and the ligand of the visualization agents can be modified to be used for new vessels detection, cancer cell detection, immunocyte detection, hepatocyte detection, cell death detection, and gene detection.
(FR)Cette invention concerne une nanoparticule contenant un lieur relié à une chaîne alcane ou alcène longue, et un procédé de préparation de ladite nanoparticule. La chaîne alkyle de C10~30 introduite avec un ligand selon la présente invention peut être revêtue sur une nanoparticule hydrophobe par l'intermédiaire d'une liaison non covalente, permettant l'introduction facile de divers ligands sur la nanoparticule, et la nanoparticule portant divers groupes fonctionnels préparée par le procédé selon l'invention peut être appliquée à la détection par fluorescence, l'IRM, la spectroscopie Raman, la détection optique, un dispositif d'imagerie TEP, SPECT, ou gamma, et le ligand des agents de visualisation peut être modifié pour être appliqué à la détection de néovaisseaux, la détection de cellules cancéreuses, la détection d'immunocytes, la détection d'hépatocytes, la détection de la mort cellulaire, et la détection de gènes.
(KO)본 발명은 긴 알칸 또는 알켄사슬에 연결된 링커를 포함하는 나노입자 및 이의 제조방법에 관한 것이다. 본 발명의 리간드가 도입된 C10~30의 알킬 사슬을 비공유 결합으로 소수성 나노입자에 코팅함으로써 나노입자에 다양한 리간드를 용이하게 도입할 수 있고, 상기 방법에 의해 제조된 다양한 기능기를 가진 나노입자를 형광탐지, MRI, 라만 분광, 광학탐지, PET, SPECT 또는 감마영상 장치에 적용될 수 있고, 상기 영상화제의 리간드를 변화시켜 신생혈관탐지, 암세포 탐지, 면역세포 탐지, 간세포 탐지, 세포사멸 탐지, 유전자 탐지에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)