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1. (WO2012105794) MAGNETIC NANOPARTICLE, HAVING A CURIE TEMPERATURE WHICH IS WITHIN BIOCOMPATIBLE TEMPERATURE RANGE, AND METHOD FOR PREPARING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/105794    International Application No.:    PCT/KR2012/000739
Publication Date: 09.08.2012 International Filing Date: 31.01.2012
IPC:
A61K 9/16 (2006.01), A61K 47/48 (2006.01), A61K 47/02 (2006.01), A61K 49/08 (2006.01)
Applicants: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION [KR/KR]; c/o, Korea Univeristy, 5-1, Anam-dong, Seongbuk-gu, Seoul 136-713 (KR) (For All Designated States Except US).
KIM, Young Keun [KR/KR]; (KR) (For US Only).
WU, Jun Hua [SG/KR]; (KR) (For US Only).
MIN, Ji Hyun [KR/KR]; (KR) (For US Only).
LEE, Ji-Sung [KR/KR]; (KR) (For US Only).
JUNG, Jae-Ho [KR/KR]; (KR) (For US Only)
Inventors: KIM, Young Keun; (KR).
WU, Jun Hua; (KR).
MIN, Ji Hyun; (KR).
LEE, Ji-Sung; (KR).
JUNG, Jae-Ho; (KR)
Agent: DANA PATENT LAW FIRM; 5th Floor, BYC Bldg., 648-1 Yeoksam-dong, Gangnam-gu Seoul 135-080 (KR)
Priority Data:
10-2011-0009824 31.01.2011 KR
Title (EN) MAGNETIC NANOPARTICLE, HAVING A CURIE TEMPERATURE WHICH IS WITHIN BIOCOMPATIBLE TEMPERATURE RANGE, AND METHOD FOR PREPARING SAME
(FR) NANOPARTICULE MAGNÉTIQUE AYANT UNE TEMPÉRATURE DE CURIE QUI EST DANS LA PLAGE DES TEMPÉRATURES BIOCOMPATIBLES, ET SON PROCÉDÉ DE PRÉPARATION
(KO) 생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법
Abstract: front page image
(EN)The present invention relates to a magnetic nanoparticle having a Curie temperature which is within the biocompatible temperature range, to a method for preparing same, and to a nanocomposite and a target-substance-detecting composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0°C to 41°C, the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the magnetic nanoparticle of the present invention may minimize adverse effects caused by the ferromagnetic properties thereof, and may be used in the effective detection and separation of biological control agents.
(FR)Cette invention concerne une nanoparticule magnétique ayant une température de Curie qui est dans la plage des températures biocompatibles, et son procédé de préparation, un nanocomposite et une composition de détection d'une substance cible contenant ladite nanoparticule magnétique. Comme la nanoparticule magnétique selon la présente invention a une température de Curie dans la plage de températures de 0 à 41°C, ses propriétés ferromagnétiques et paramagnétiques peuvent être contrôlées dans une plage de températures biocompatibles, à une température à laquelle un agent de régulation biologique n'est pas détruit, et la température de la nanoparticule magnétique est ajustée pour réguler ses propriétés magnétiques pour qu'elles ne puissent être utilisées que quand des propriétés ferromagnétiques sont requises, comme dans le cas de l'amplification du signal dans le domaine de la détection, de la séparation, et de l'administration d'agents de régulation biologiques. Par conséquent, la nanoparticule magnétique selon la présente invention peut réduire au minimum les effets secondaires provoqués par ses propriétés ferromagnétiques, et peut être utilisée pour détecter et séparer efficacement des agents de régulation biologiques.
(KO)본 발명은 생첵 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자, 이의 제조 방법, 이를 포함하는 나노 복합체 및 표적 물질 탐지용 조성물에 관한 것이다. 본 발명의 자성 나노입자는 0℃ 내지 41℃의 온도 범위에서 큐리 온도를 가지기 때문에, 생물제재가 파괴되지 않는 생체 적합 온도 내에서 강자성 및 상자성 특성을 제어할 수 있고, 생물제재의 검지, 분리 및 전달 등의 분야에서 신호 증폭과 같은 강자성 특성이 요구되는 경우에만 그 특성을 활용할 수 있도록 온도를 조절하여 자성 특성을 제어할 수 있다. 이에 따라, 본 발명의 자성 나노입자는 강자성 특성에 따른 부작용을 최소화할 수 있고, 생물제재의 효과적인 검지 및 분리 등에 활용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)