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Pub. No.:    WO/2012/105635    International Application No.:    PCT/JP2012/052336
Publication Date: 09.08.2012 International Filing Date: 02.02.2012
C07D 473/28 (2006.01), A61K 31/522 (2006.01), A61P 25/04 (2006.01), A61P 25/22 (2006.01), A61P 25/24 (2006.01), A61P 29/02 (2006.01), A61P 43/00 (2006.01)
Applicants: Dainippon Sumitomo Pharma Co., Ltd. [JP/JP]; 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418524 (JP) (For All Designated States Except US).
ADACHI, Keiji [JP/JP]; (JP) (For US Only).
NAKAI, Yoko [JP/JP]; (JP) (For US Only).
FURUTA, Tomoyuki [JP/JP]; (JP) (For US Only).
FUJII, Yuki [JP/JP]; (JP) (For US Only)
Inventors: ADACHI, Keiji; (JP).
NAKAI, Yoko; (JP).
FURUTA, Tomoyuki; (JP).
FUJII, Yuki; (JP)
Agent: SAMEJIMA, Mutsumi; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001 (JP)
Priority Data:
2011-021538 03.02.2011 JP
(JA) 2-オキシ置換8-オキソジヒドロプリン誘導体
Abstract: front page image
(EN)The present invention provides an agent for treating or preventing disorders in which FAAH is involved, and specifically depression, anxiety, pain, or other disorders. The agent comprises a compound represented by formula (1) or a pharmaceutically acceptable salt thereof (in the formula, W represents a hydrogen atom, a halogen atom, or the like; A represents an aryl group, an alkyl group optionally substituted by an aryl group, or the like; one of X and Y is a disubstituted alkylaminocarbonyl group or the like; and the other of X and Y is a hydrogen atom, an alkyl group, or the like).
(FR)L'invention concerne un agent destiné à traiter ou à prévenir des troubles dans lesquels intervient la FAAH, et spécifiquement la dépression, l'anxiété, la douleur ou d'autres troubles. Cet agent comprend un composé représenté par la formule (1) ou un sel pharmaceutiquement acceptable de celui-ci (dans la formule, W représente un atme d'hydrogène, un atome d'halogène ou analogue; A représente un groupe aryle, un groupe alkyle éventuellement substitué par un groupe aryle ou analogue; soit X, soit Y représente un groupe alkylaminocarbonyle disubstitué ou analogue, l'autre (X ou Y) représentant un atome d'hydrogène, un groupe alkyle ou analogue).
(JA) 本発明は、下記式(1)で表される化合物またはその薬学的に許容される塩(式中、Wは水素原子、ハロゲン原子等であり、Aはアリール基等で置換されていてもよいアルキル基、アリール基等であり、XおよびYのいずれか一方はジ置換のアルキルアミノカルボニル基等であり、他方は水素原子、アルキル基等である)を含むFAAHが関与する疾患、具体的にはうつ病、不安症または疼痛等の疾患に対する治療薬または予防薬を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)