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1. (WO2012104843) AFFINITY MATURATED T CELL RECEPTORS AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/104843    International Application No.:    PCT/IL2012/000061
Publication Date: 09.08.2012 International Filing Date: 05.02.2012
IPC:
C12N 15/09 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO.LTD. at the Weizmann Institute of Science [IL/IL]; P.O. Box 95 76100 Rehovot (IL) (For All Designated States Except US).
EISENBACH, Lea [IL/IL]; (IL) (For US Only).
GOZLAN, Yosi [IL/IL]; (IL) (For US Only).
TZEHOVAL, Esther [IL/IL]; (IL) (For US Only)
Inventors: EISENBACH, Lea; (IL).
GOZLAN, Yosi; (IL).
TZEHOVAL, Esther; (IL)
Agent: WEBB & CO.; P.O. Box 2189 76121 Rehovot (IL)
Priority Data:
61/439,894 06.02.2011 US
Title (EN) AFFINITY MATURATED T CELL RECEPTORS AND USE THEREOF
(FR) RÉCEPTEURS DE LYMPHOCYTES T À MATURATION D'AFFINITÉ ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
(FR)La présente invention concerne des procédés et des systèmes qui permettent d'augmenter l'affinité d'un récepteur de lymphocytes T (TCR) pour son ligand en soumettant le gène TCR à une hyper mutation somatique. La présente invention concerne en outre l'utilisation de TCR à maturation d'affinité pour créer des lymphocytes T réactifs contre un antigène choisi.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application