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1. (WO2012104831) SURFACE-MODIFIED HEAVY METAL NANOPARTICLES, COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/104831    International Application No.:    PCT/IL2011/000854
Publication Date: 09.08.2012 International Filing Date: 03.11.2011
IPC:
B22F 9/00 (2006.01)
Applicants: METALLO THERAPY LTD. [IL/IL]; P.O. Box 437 20200 Shefaram (IL) (For All Designated States Except US).
AYOUB, Amal [IL/IL]; (IL) (For US Only).
SAFADI, Nassim [IL/IL]; (IL) (For US Only).
BASHEER, Sobhi [IL/IL]; (IL) (For US Only)
Inventors: AYOUB, Amal; (IL).
SAFADI, Nassim; (IL).
BASHEER, Sobhi; (IL)
Agent: WEBB & CO.; P.O. Box 2189 76121 Rehovot (IL)
Priority Data:
61/439,004 03.02.2011 US
Title (EN) SURFACE-MODIFIED HEAVY METAL NANOPARTICLES, COMPOSITIONS AND USES THEREOF
(FR) NANOPARTICULES EN MÉTAL LOURD À SURFACE MODIFIÉE, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
Abstract: front page image
(EN)There are provided surface-modified heavy metal nanoparticles, comprising a heavy metal core and a coating layer, the coating layer comprising at least one ligand, conjugated to polyethylene glycol, wherein the at least one ligand is selected from N-acetyl cysteine, albumin, cysteine, methionine, glutathione, amino thiols, thio-carboxylic acids, ammonia, amines, diamines or any combination thereof. Further provided are compositions comprising the same and uses thereof in treatment and diagnosis of various conditions.
(FR)L'invention concerne des nanoparticules en métal lourd à surface modifiée, comprenant un noyau en métal lourd et une couche de revêtement, la couche de revêtement comprenant au moins un ligand, conjugué au polyéthylène glycol, lesdits ligands étant sélectionnés dans N-acétyle cystéine, albumine, cystéine, méthionine, glutathion, amino thiols, acides thio-carboxylique, ammoniac, amines, diamines ou une combinaison quelconque de ceux-ci. L'invention concerne en outre des compositions les comprenant ainsi que leurs utilisations dans le traitement et le diagnostic de divers états.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)