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1. (WO2012104340) MARKERS OF MELANOMA AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/104340    International Application No.:    PCT/EP2012/051663
Publication Date: 09.08.2012 International Filing Date: 01.02.2012
IPC:
C12Q 1/68 (2006.01)
Applicants: AZIENDA OSPEDALIERA UNIVERSITARIA SENESE [IT/IT]; Strada delle Scotte 14 I-53100 Siena (IT) (For All Designated States Except US).
CENTRO DI RIFERIMENTO ONCOLOGICO - ISTITUTO NAZIONALE TUMORI - AVIANO [IT/IT]; Via Franco Gallini 2 I-33081 Aviano (PN) (IT) (For All Designated States Except US).
SIGALOTTI, Luca [IT/IT]; (IT) (For US Only).
MAIO, Michele [IT/IT]; (IT) (For US Only)
Inventors: SIGALOTTI, Luca; (IT).
MAIO, Michele; (IT)
Agent: CAPASSO, Olga; Via Vincenzo Bellini, 20 I-00198 Rome (IT)
Priority Data:
11152864.2 01.02.2011 EP
Title (EN) MARKERS OF MELANOMA AND USES THEREOF
(FR) MARQUEURS DE MÉLANOME ET LEURS UTILISATIONS
Abstract: front page image
(EN)The invention relates to a method for determining prognosis, predicting or monitoring response to therapy of patients affected by melanoma through the evaluation of the methylation of different genomic DNA sequences, including the Long Interspersed Nucleotide Element- 1 (LINE-1) repetitive DNA sequences and/or the concomitant methylation profile of specific groups of genes defined as methylation signature.
(FR)L'invention concerne un procédé de détermination du pronostic, de prédiction ou de surveillance d'une réponse à une thérapie, de patients atteints par un mélanome, par l'évaluation de la méthylation de différentes séquences d'ADN génomique, comprenant les séquences répétitives d'ADN d'élément 1 nucléotidique entrecoupé long (LINE-1) et/ou le profil concomitant de méthylation de groupes spécifiques de gènes définis en tant que signature de méthylation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)