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1. (WO2012104305) ANTIMICROBIAL 4-OXOQUINOLIZINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/104305    International Application No.:    PCT/EP2012/051563
Publication Date: 09.08.2012 International Filing Date: 31.01.2012
Chapter 2 Demand Filed:    30.11.2012    
IPC:
A61K 31/4375 (2006.01), A61K 31/444 (2006.01), A61K 31/4545 (2006.01), A61K 31/4709 (2006.01), A61K 31/496 (2006.01), A61K 31/506 (2006.01), A61K 38/12 (2006.01), C07D 455/02 (2006.01), A61P 31/04 (2006.01)
Applicants: EVOLVA SA [CH/CH]; Duggingerstrasse 23 CH-4153 Reinach (CH) (For All Designated States Except US).
HEIM, Jutta [DE/CH]; (CH) (For US Only).
SCHNEIDER, Peter [CH/CH]; (CH) (For US Only).
ROUSSEL, Patrick [FR/FR]; (FR) (For US Only).
MILLIGAN, Daniel [US/US]; (US) (For US Only).
DALE, Glenn [CH/CH]; (CH) (For US Only).
BARTELS, Christian [CH/CH]; (CH) (For US Only)
Inventors: HEIM, Jutta; (CH).
SCHNEIDER, Peter; (CH).
ROUSSEL, Patrick; (FR).
MILLIGAN, Daniel; (US).
DALE, Glenn; (CH).
BARTELS, Christian; (CH)
Agent: HØIBERG A/S; St. Kongensgade 59 A DK-1264 Copenhagen K (DK)
Priority Data:
61/438,543 01.02.2011 US
Title (EN) ANTIMICROBIAL 4-OXOQUINOLIZINES
(FR) 4-OXOQUINOLIZINES ANTIMICROBIENNES
Abstract: front page image
(EN)This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.
(FR)Cette invention concerne de nouveaux composés de 4-oxoquinolizine et leurs utilisations pour une série d'antibiotiques à large spectre n'ayant pas de résistance croisée avec des classes existantes ou émergentes d'antibiotiques. De plus, les nouveaux composés de 4-oxoquinolizine sont utiles contre les pathogènes de catégorie CDC A et B. L'invention concerne en outre des compositions pharmaceutiques comprenant certaines 4-oxoquinolizines en combinaison avec des concentrations sub-inhibitrices de polymyxine B contre des isolats cliniques qui sont résistants aux quinolones, carbapénems et à d'autres agents antimicrobiens.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)