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1. (WO2012104224) CASPASE-2 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/104224    International Application No.:    PCT/EP2012/051367
Publication Date: 09.08.2012 International Filing Date: 27.01.2012
IPC:
C07K 14/81 (2006.01), C12N 9/64 (2006.01), A61K 38/55 (2006.01), A61P 25/28 (2006.01)
Applicants: CHIESI FARMACEUTICI S.p.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma (IT) (For All Designated States Except US).
CHAUVIER, David [FR/IT]; (IT) (For US Only).
JACOTOT, Etienne [FR/--]; (IT) (For US Only)
Inventors: CHAUVIER, David; (IT).
JACOTOT, Etienne; (IT)
Agent: MINOJA, Fabrizio; Bianchetti Bracco Minoja S.R.L. Via Plinio, 63 I-20129 Milano (IT)
Priority Data:
11152892.3 01.02.2011 EP
Title (EN) CASPASE-2 INHIBITORS
(FR) INHIBITEURS DE CASPASE-2
Abstract: front page image
(EN)The invention relates to novel compounds, pharmaceutical compositions and use thereof, which inhibit pro-apoptotic caspase-2 to prevent and/or treat diseases and injuries where caspase-2 activity is implicated, in particular neonatal brain ischemia.
(FR)Cette invention concerne de nouveaux composés, des compositions pharmaceutiques et leur utilisation pour inhiber la caspase-2 pro-apoptotique et prévenir et/ou traiter les maladies et les lésions où l'activité caspase-2 est impliquée, en particulier, l'ischémie cérébrale chez le nouveau-né.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)