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1. (WO2012103783) USE OF ARTEMISINE DERIVATIVES AND PHARMACEUTICAL SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103783    International Application No.:    PCT/CN2012/070401
Publication Date: 09.08.2012 International Filing Date: 16.01.2012
IPC:
C07D 493/18 (2006.01), A61K 31/357 (2006.01), A61P 35/02 (2006.01)
Applicants: RUI JIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE [CN/CN]; Shanghai Institute of Hematology No.197 Rui Jin Er Road Luwan District, Shanghai 200025 (CN) (For All Designated States Except US).
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; No.555 Zu Chong Zhi Road, Zhangjiang Hi-tech Park Pudong District, Shanghai 201203 (CN) (For All Designated States Except US).
MI, Jianqing [CN/CN]; (CN) (For US Only).
LI, Ying [CN/CN]; (CN) (For US Only).
PENG, Yu [CN/CN]; (CN) (For US Only).
ZHANG, Yu [CN/CN]; (CN) (For US Only).
NIE, Ruimin [CN/CN]; (CN) (For US Only).
LIU, Jingjing [CN/CN]; (CN) (For US Only).
Wang, Jin [CN/CN]; (CN) (For US Only).
WANG, Yueying [CN/CN]; (CN) (For US Only).
CAI, Xun [CN/CN]; (CN) (For US Only).
LI, Yang [CN/CN]; (CN) (For US Only).
CHEN, Saijuan [CN/CN]; (CN) (For US Only).
WANG, Zhenyi [CN/CN]; (CN) (For US Only)
Inventors: MI, Jianqing; (CN).
LI, Ying; (CN).
PENG, Yu; (CN).
ZHANG, Yu; (CN).
NIE, Ruimin; (CN).
LIU, Jingjing; (CN).
Wang, Jin; (CN).
WANG, Yueying; (CN).
CAI, Xun; (CN).
LI, Yang; (CN).
CHEN, Saijuan; (CN).
WANG, Zhenyi; (CN)
Agent: HANGHAI DANROSE & RAYMOND INTELLECTUAL PROPERTY AGENCY CO. LTD.; MIAO, Liming Room 2106-2107, Jun Feng International Fortune Plaza No.1619, Dalian Rd. HongKou District, Shanghai 200086 (CN)
Priority Data:
201110034201.X 31.01.2011 CN
Title (EN) USE OF ARTEMISINE DERIVATIVES AND PHARMACEUTICAL SALTS THEREOF
(FR) UTILISATION DE DÉRIVÉS D'ARTÉMISINE ET SELS PHARMACEUTIQUES DE CEUX-CI
(ZH) 一种青蒿素衍生物及其药用盐的应用
Abstract: front page image
(EN)Use of artemisine derivatives and pharmaceutical salts thereof is disclosed by the present invention. Arteether dimer amine, the artemisine derivatives and pharmaceutical salts thereof can inhibit the proliferation of leukemic cells, block the cycle of leukemic cells, and induce the apoptosis of leukemic cells. Arteether dimer amine, the artemisine derivatives and pharmaceutical salts thereof in the present invention can be used to manufacture medicaments in treating leukemia, especially in treating acute leukemia, more especially in treating acute myeloid leukemia.
(FR)La présente invention concerne l'utilisation de dérivés d'artémisine et des sels pharmaceutiques de ceux-ci. Les dérivés d'artémisine, (dimère d'arteéther)amine, et les sels pharmaceutiques de ceux-ci peuvent inhiber la prolifération de cellules leucémiques, bloquer le cycle de cellules leucémiques, et induire l'apoptose de cellules leucémiques. Les dérivés d'artémisine, (dimère d'arteéther)amine, et les sels pharmaceutiques de ceux-ci dans la présente invention peuvent être utilisés pour fabriquer des médicaments dans le traitement de la leucémie, en particulier dans le traitement d'une leucémie aiguë, plus particulièrement dans le traitement de la leucémie myéloïde aiguë.
(ZH)本发明公开了一种青蒿素衍生物及其药用盐的应用。该青蒿素衍生物二蒿乙醚基胺及其药用盐能够抑制白血病细胞的增殖,阻滞白血病细胞周期,诱导白血病细胞凋亡。本发明的青蒿素衍生物二蒿乙醚基胺及其药用盐能用于制备治疗白血病的药物,特别是用于制备治疗急性白血病的药物,更特别是用于制备治疗急性髓细胞性白血病的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)