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1. (WO2012103777) COMPOUND ISOLATED FROM MONASCUS PURPUREUS, PREPARATION METHOD THEREFOR AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103777    International Application No.:    PCT/CN2012/070169
Publication Date: 09.08.2012 International Filing Date: 10.01.2012
IPC:
C07D 309/32 (2006.01), A61K 31/351 (2006.01), A61P 3/06 (2006.01), A61P 9/10 (2006.01)
Applicants: BEIJING PEKING UNIVERSITY WBL BIOTECH CO., LTD. [CN/CN]; Block A, Room 701-705 No.30 South Haidian Road Haidian District, Beijing 100080 (CN) (For All Designated States Except US).
DUAN, Zhenwen [CN/CN]; (CN) (For US Only).
GUO, Shuren [CN/CN]; (CN) (For US Only).
LI, Xuemei [CN/CN]; (CN) (For US Only).
LIU, Chunli [CN/CN]; (CN) (For US Only)
Inventors: DUAN, Zhenwen; (CN).
GUO, Shuren; (CN).
LI, Xuemei; (CN).
LIU, Chunli; (CN)
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street Xicheng District, Beijing 100037 (CN)
Priority Data:
201110033924.8 01.02.2011 CN
Title (EN) COMPOUND ISOLATED FROM MONASCUS PURPUREUS, PREPARATION METHOD THEREFOR AND USES THEREOF
(FR) COMPOSÉ ISOLÉ À PARTIR DE MONASCUS PURPUREUS, SON PROCÉDÉ DE PRÉPARATION ET SES UTILISATIONS
(ZH) 一种从红曲中分离的化合物、其制备方法及用途
Abstract: front page image
(EN)Disclosed is a compound isolated from monascus purpureus, a preparation method therefor and uses thereof. Specifically, the compound is as represented in formula I, or pharmaceutically acceptable salts thereof, where R1 is selected from hydrogen, hydroxyl group, C1-6 straight-chain or branched-chain alkoxy group, [formula II], [formula III] and [formula IV]; R2 is hydrogen or alkyl group; R3 is selected from hydrogen, hydroxyl group, C1-6 straight-chain or branched-chain alkoxy group. Also disclosed in the present invention is a pharmaceutical composition containing the compound. The compound of the present invention has an inhibitive effect on HMG-CoA reductase. Formula I.
(FR)Cette invention concerne un composé isolé à partir de Monascus purpureus, son procédé de préparation et ses utilisations. Plus spécifiquement, le composé est tel que représenté dans la Formule I, ou des sels de qualité pharmaceutique de celui-ci, où R1 est choisi parmi un atome d'hydrogène, un groupe hydroxyle, un groupe alcoxy C1-6 à chaîne droite ou ramifiée, [formule II], [formule III] et [formule IV]; R2 est un atome d'hydrogène ou un groupe alkyle; et R3 est choisi parmi un atome d'hydrogène, un groupe hydroxyle, et un groupe alcoxy C1-6 à chaîne droite ou ramifiée. Cette invention concerne également une composition pharmaceutique contenant le composé. Le composé selon la présente invention a un effet inhibiteur sur la HMG-CoA réductase. Formule I.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)