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1. (WO2012103532) COMBINATORIAL VITAMIN D AND PROBIOTIC THERAPY FOR INFLAMMATORY BOWEL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103532    International Application No.:    PCT/US2012/023050
Publication Date: 02.08.2012 International Filing Date: 28.01.2012
IPC:
A01N 45/00 (2006.01)
Applicants: MAZMANIAN, Sarkis, K. [US/US]; (US).
SHEN, Yue [CN/US]; (US).
HEWISON, Martin [US/GB]; (US).
LAGISHETTY, Venu [US/IN]; (US)
Inventors: MAZMANIAN, Sarkis, K.; (US).
SHEN, Yue; (US).
HEWISON, Martin; (US).
LAGISHETTY, Venu; (US)
Agent: TUN, Richard, Y., M.; BERLINER & ASSOCIATES 555 West Fifth Street, 31st Floor Los Angeles, CA 90013 (US)
Priority Data:
61/437,478 28.01.2011 US
Title (EN) COMBINATORIAL VITAMIN D AND PROBIOTIC THERAPY FOR INFLAMMATORY BOWEL DISEASE
(FR) THÉRAPIE COMBINATOIRE DE VITAMINE D ET DE PROBIOTIQUES POUR L'AFFECTION ABDOMINALE INFLAMMATOIRE
Abstract: front page image
(EN)A method of increasing the percentage of mouse and human Tregs is provided comprising providing B.fragilis or PSA and vitamin D or vitamin D metabolite to said mouse or human. Also, a method for treating inflammatory bowel diseases in an individual is presented where the individual is given a combination of vitamin D and B.fragilis or PSA. Such a treatment may be particularly effective in individuals who are either Vitamin D insufficient or deficient.
(FR)La présente invention concerne un procédé d'augmentation du pourcentage de lymphocytes T régulateurs murins et humains comprenant la fourniture de B.fragilis ou polysaccharide A et de la vitamine D ou de métabolite de la vitamine D à ladite souris ou au dit humain. L'invention concerne également un procédé pour le traitement de l'affection abdominale inflammatoire chez un sujet par l'administration au sujet d'une combinaison de vitamine D et de B.fragilis ou polysaccharide A. Un tel traitement peut être particulièrement efficace chez des sujets qui souffrent d'une insuffisance ou d'une déficience en vitamine D.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)