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1. (WO2012103523) NOVEL MODULATORS OF DEVELOPMENT OF ADIPOCYTE AND CANCER CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103523    International Application No.:    PCT/US2012/023034
Publication Date: 02.08.2012 International Filing Date: 27.01.2012
IPC:
A01N 47/28 (2006.01), A61K 31/17 (2006.01)
Applicants: CITY OF HOPE [US/US]; 1500 East Duarte Road Duarte, CA 91010-3000 (US).
RAHBAR, Samuel [US/US]; (US).
FIGAROLA, James [US/US]; (US).
LINCOLN, Christopher [US/US]; (US).
HORNE, David [US/US]; (US).
MOONEY, Rachael [US/US]; (US).
POLEWSKI. Monika [US/US]; (US).
SOMLO, George [US/US]; (US).
YANG, Lixin [US/US]; (US)
Inventors: RAHBAR, Samuel; (US).
FIGAROLA, James; (US).
LINCOLN, Christopher; (US).
HORNE, David; (US).
MOONEY, Rachael; (US).
POLEWSKI. Monika; (US).
SOMLO, George; (US).
YANG, Lixin; (US)
Agent: WANG, Yingli; Perkins Coie LLP P.O. Box 1208 Seattle, WA 98111-1208 (US)
Priority Data:
61/436,958 27.01.2011 US
Title (EN) NOVEL MODULATORS OF DEVELOPMENT OF ADIPOCYTE AND CANCER CELLS
(FR) NOUVEAUX MODULATEURS DU DÉVELOPPEMENT DES ADIPOCYTES ET DES CELLULES CANCÉREUSES
Abstract: front page image
(EN)One aspect of the disclosure relates to derivatives of aryl and heterocyclicureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea, curcumin, and 1,3-diazetidine-2,4-dione, and pharmaceutical compositions thereof. The derivatives disclosed herein can modulate development of adipocytes and various cancer cells, including resistant cancer cells and cancer stem cells. Another aspect of the disclosure relates to the use of the derivatives and pharmaceutical compositions disclosed herein in treatment of obesity and various cancers.
(FR)La présente invention concerne des dérivés d'aryle et d'hétérocyclicuréidoaryle et d'acides carboxamido-isobutyriques hétérocycliques, de dichlorophénylurée, de curcumine, et de 1,3-diazétidine-2,4-dione, et des compositions pharmaceutiques de ceux-ci. Les dérivés présentement décrits peuvent moduler le développement d'adipocytes et de différentes cellules cancéreuses, comprenant des cellules cancéreuses résistantes et des cellules souches cancéreuses. Un autre aspect de la description concerne l'utilisation des dérivés et compositions pharmaceutiques présentement décrits dans le traitement de l'obésité et de différents cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)