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1. WO2012103333 - TETRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

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Publication Number WO/2012/103333
Publication Date 02.08.2012
International Application No. PCT/US2012/022721
International Filing Date 26.01.2012
IPC
C07D 257/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
06with nitrogen atoms directly attached to the ring carbon atom
A61K 31/41 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61P 3/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
CPC
A61K 31/41
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 257/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
C07D 257/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
06with nitrogen atoms directly attached to the ring carbon atom
Applicants
  • ZAFGEN, INC. [US]/[US] (AllExceptUS)
  • DYKE, Hazel, Joan [GB]/[GB] (UsOnly)
  • PALLIN, Thomas, David [GB]/[GB] (UsOnly)
  • CRAMP, Susan, Mary [GB]/[GB] (UsOnly)
Inventors
  • DYKE, Hazel, Joan
  • PALLIN, Thomas, David
  • CRAMP, Susan, Mary
Agents
  • KAVANAUGH, Theresa, C.
Priority Data
61/436,26526.01.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TETRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
(FR) COMPOSÉS DE TÉTRAZOLE ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
Abstract
(EN) Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
(FR) La présente invention concerne des composés de tétrazole et leur utilisation dans le traitement de troubles médicaux, tels que l'obésité. La présente invention concerne des compositions pharmaceutiques et des procédés de fabrication de différents composés de tétrazole. Il est envisagé que les composés aient une activité contre la méthionyle aminopeptidase 2.
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