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1. (WO2012103305) USE OF (S) - ESMOLOL FOR CONTROLLING VENOUS IRRITATION ASSOCIATED WITH THE TREATMENT OF A CARDIAC DISORDER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103305    International Application No.:    PCT/US2012/022679
Publication Date: 02.08.2012 International Filing Date: 26.01.2012
Chapter 2 Demand Filed:    27.11.2012    
IPC:
A61K 31/24 (2006.01), A61P 9/06 (2006.01)
Applicants: BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway Deerfield, IL 60015 (US) (For All Designated States Except US).
BAXTER HEALTHCARE S.A. [CH/CH]; Thurgauerstrasse 130 CH-8152 Glattpark (Opfikon) (CH) (For All Designated States Except US).
GASS, Jerome, H. [US/US]; (US) (For US Only).
MCKEE, Jeff [US/US]; (US) (For US Only).
RABINOW, Barrett [US/US]; (US) (For US Only)
Inventors: GASS, Jerome, H.; (US).
MCKEE, Jeff; (US).
RABINOW, Barrett; (US)
Agent: LAWRENCE, Andrew, M.; Marshall, Gerstein & Borun LLP 233 S. Wacker Drive 6300 Willis Tower Chicago, IL 60606-6357 (US)
Priority Data:
61/436,995 27.01.2011 US
Title (EN) USE OF (S) - ESMOLOL FOR CONTROLLING VENOUS IRRITATION ASSOCIATED WITH THE TREATMENT OF A CARDIAC DISORDER
(FR) UTILISATION DE (S)-ESMOLOL DANS LA RÉGULATION DE L'IRRITATION VEINEUSE ASSOCIÉE AU TRAITEMENT D'UN TROUBLE CARDIAQUE
Abstract: front page image
(EN)A pharmaceutical composition comprising (S)-methyl-3-[4-(2-hydroxy-3- isopropylamino) propoxy] phenylpropionate in a concentration between about 75 mM and about 150 mM, which is substantially free of the R-isomer or pharmaceutically acceptable salt thereof, is provided. A method of treating a cardiac disorder is also provided and includes administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate hydrochloride, wherein the (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate hydrochloride is present at a concentration between about 75 mM and about 150 mM and wherein the pharmaceutical composition is substantially free of (R)-methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate or pharmaceutically acceptable salt thereof.
(FR)La présente invention concerne une composition pharmaceutique comprenant du (S)-méthyle-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phénylpropionate dans une concentration comprise entre environ 75 mM et environ 150 mM, qui est sensiblement exempte du R-isomère ou d'un sel pharmaceutiquement acceptable de celui-ci. L'invention porte en outre sur une méthode de traitement d'un trouble cardiaque, comprenant l'administration, à un sujet en ayant besoin, d'une quantité thérapeutiquement efficace d'une composition pharmaceutique comprenant du chlorhydrate (S)-méthyle-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phénylpropionate. Ledit chlorhydrate de (S)-méthyle-3-[4-(2-hydroxy-3-isopropylamino)propoxy] phénylpropionate est présent dans une concentration comprise entre environ 75 mM et environ 150 mM, et ladite composition pharmaceutique est sensiblement exempte de (R)-méthyle-3-[4-(2-hydroxy-3-isopropylamino)propoxy] phénylpropionate ou d'un sel pharmaceutiquement acceptable de celui-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)