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1. (WO2012103295) SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103295    International Application No.:    PCT/US2012/022662
Publication Date: 02.08.2012 International Filing Date: 26.01.2012
IPC:
A61K 31/497 (2006.01), C07D 403/00 (2006.01)
Applicants: UNIVERSITY OF ROCHESTER [US/US]; 601 Elmwood Avenue Box OTT Rochester, New York 14642 (US) (For All Designated States Except US).
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA [US/US]; Varner Hall, 3835 Holdrege Street Lincoln, Nebraska 68583-0745 (US) (For All Designated States Except US).
DUNMAN, Paul M. [US/US]; (US) (For US Only).
OLSON, Patrick D. [US/US]; (US) (For US Only).
CHILDERS, Wayne [US/US]; (US) (For US Only).
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; Broad and Montgomery Avenue 1801 N. Broad Street Philadelphia, PA 19122 (US) (For All Designated States Except US)
Inventors: DUNMAN, Paul M.; (US).
OLSON, Patrick D.; (US).
CHILDERS, Wayne; (US)
Agent: PREATT, John S.; KILPATRICK TOWNSEND & STOCKTON LLP 1100 Peachtree Street NE Suite 2800 Atlanta, Georgia 30309 (US)
Priority Data:
61/436,342 26.01.2011 US
Title (EN) SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
(FR) INHIBITEURS D'ARNSE À PETITES MOLÉCULES ET MÉTHODES D'UTILISATION
Abstract: front page image
(EN)Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
(FR)L'invention concerne des inhibiteurs à petites molécules de la ribonucléase bactérienne (par ex., RnpA) ainsi que des méthodes pour leur synthèse et leur utilisation. Les méthodes d'utilisation des composés consistent à traiter et à prévenir les infections microbiennes, ainsi qu'à inhiber la ribonucléase bactérienne. L'invention concerne également des méthodes d'identification de composés pour traiter ou prévenir une infection microbienne.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)