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1. (WO2012103250) COLON CANCER GENE EXPRESSION SIGNATURES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103250    International Application No.:    PCT/US2012/022594
Publication Date: 02.08.2012 International Filing Date: 25.01.2012
IPC:
G01N 33/48 (2006.01), C07H 21/00 (2006.01), C12Q 1/68 (2006.01)
Applicants: ALMAC DIAGNOSTICS LIMITED [GB/GB]; 20 Seagoe Industrial Estate Almac House Craigavon BT63 5QD (GB) (For All Designated States Except US).
HARKIN, Denis, Paul [IE/GB]; (GB) (For US Only).
PROUTSKI, Vitali [RU/GB]; (GB) (For US Only).
BLACK, Julie [GB/GB]; (GB) (For US Only).
KERR, Peter [IE/GB]; (GB) (For US Only).
KENNEDY, Richard [GB/GB]; (GB) (For US Only).
WINTER, Andreas [DE/DE]; (DE) (For US Only).
DAVISON, Timothy [US/US]; (US) (For US Only).
BYLESJO, Max [SE/GB]; (GB) (For US Only).
FARZTDINOV, Vadim [RU/GB]; (GB) (For US Only).
WILSON, Claire [GB/GB]; (GB) (For US Only).
HOLT, Robert, James [GB/GB]; (GB) (For US Only)
Inventors: HARKIN, Denis, Paul; (GB).
PROUTSKI, Vitali; (GB).
BLACK, Julie; (GB).
KERR, Peter; (GB).
KENNEDY, Richard; (GB).
WINTER, Andreas; (DE).
DAVISON, Timothy; (US).
BYLESJO, Max; (GB).
FARZTDINOV, Vadim; (GB).
WILSON, Claire; (GB).
HOLT, Robert, James; (GB)
Agent: GRISWOLD, Ian, James; Johnson, Marcou & Isaacs, LLC 317A East Liberty Street Savannah, GA 31401 (US)
Priority Data:
61/435,922 25.01.2011 US
Title (EN) COLON CANCER GENE EXPRESSION SIGNATURES AND METHODS OF USE
(FR) SIGNATURES D'EXPRESSION GÉNIQUE POUR LE CANCER DU CÔLON ET MÉTHODES D'UTILISATION
Abstract: front page image
(EN)A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer.
(FR)L'invention concerne une signature d'expression génique pour le cancer du côlon, des micro-réseaux la comprenant et des méthodes d'utilisation de la signature d'expression génique dans le cancer du côlon. La signature d'expression génique est particulièrement utile pour établir le pronostic pour un patient chez lequel on a diagnostiqué un cancer du côlon, tel qu'un cancer du côlon de stade II. La signature génétique de l'invention est également utile pour déterminer l'efficacité d'une résection chirurgicale avec ou sans chimiothérapie adjuvante, ainsi que pour déterminer une éventuelle récurrence du cancer chez des patients atteints du cancer du côlon.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)