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1. (WO2012103187) METHODS OF DIAGNOSING AND TREATING AGE-RELATED MACULAR DEGENERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103187    International Application No.:    PCT/US2012/022511
Publication Date: 02.08.2012 International Filing Date: 25.01.2012
IPC:
C12Q 1/68 (2006.01), G01N 33/50 (2006.01), A61K 38/17 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office Of Technology Transfer National Institutes Of Health 6011 Executive Boulevard, Suite 325 Msc 7660 Bethesda, MD 20892-7660 (US) (For All Designated States Except US).
WEI, Lai [CN/US]; (US) (For US Only).
NUSSENBLATT, Robert [US/US]; (US) (For US Only).
LIU, Baoying [US/US]; (US) (For US Only).
CHAN, Chi-chao [US/US]; (US) (For US Only)
Inventors: WEI, Lai; (US).
NUSSENBLATT, Robert; (US).
LIU, Baoying; (US).
CHAN, Chi-chao; (US)
Agent: CALDWELL, John, W.; Woodcock Washburn LLP Cira Centre, 12th Floor 2929 Arch Street Philadelphia, PA 19104-2891 (US)
Priority Data:
61/435,989 25.01.2011 US
Title (EN) METHODS OF DIAGNOSING AND TREATING AGE-RELATED MACULAR DEGENERATION
(FR) MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
Abstract: front page image
(EN)The present invention is directed to methods of diagnosing the presence, severity, or predisposition for development of age-related macular degeneration in a patient based on the frequency of IL-17RC+ cells and or methylation of the promoter of lL17RC gene. Methods of treated age-related macular degeneration are also described.
(FR)La présente invention a pour objet des méthodes de diagnostic de la présence, de la gravité, ou de la prédisposition au développement de la dégénérescence maculaire liée à l'âge chez un patient, basées sur la fréquence des cellules IL-17RC+ et/ou la méthylation du promoteur du gène lL17RC. La présente invention concerne également des méthodes de traitement de la dégénérescence maculaire liée à l'âge.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)