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1. (WO2012103105) PROCESSES FOR PREPARING RALTEGRAVIR AND INTERMEDIATES IN THE PROCESSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103105    International Application No.:    PCT/US2012/022385
Publication Date: 02.08.2012 International Filing Date: 24.01.2012
IPC:
C07D 239/557 (2006.01)
Applicants: ASSIA CHEMICAL INDUSTRIES LTD. [IL/IL]; 2 Denmark Street 49517 Petach Tikva (IL) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road P.O. Box 1090 North Wales, PA 19454-1090 (US) (BB only).
HEDVATI, Lilach [IL/IL]; (IL) (For US Only).
EREZ, Rotem [IL/IL]; (IL) (For US Only).
COHEN, Meital [IL/IL]; (IL) (For US Only).
KANSAL, Vinod, Kumar [IN/IN]; (IN) (For US Only).
RANJAN, Harish [IN/IN]; (IN) (For US Only).
DAS, Debashish [IN/IN]; (IN) (For US Only).
JAISWAL, Sanjay [IN/IN]; (IN) (For US Only).
SUBBIREDDY, Elluru [IN/IN]; (IN) (For US Only)
Inventors: HEDVATI, Lilach; (IL).
EREZ, Rotem; (IL).
COHEN, Meital; (IL).
KANSAL, Vinod, Kumar; (IN).
RANJAN, Harish; (IN).
DAS, Debashish; (IN).
JAISWAL, Sanjay; (IN).
SUBBIREDDY, Elluru; (IN)
Agent: BIRDE, Patrick, J.; Kenyon & Kenyon LLP One Broadway New York, NY 10004-1050 (US)
Priority Data:
61/496,389 13.06.2011 US
61/467,194 24.03.2011 US
61/545,876 11.10.2011 US
61/435,538 24.01.2011 US
Title (EN) PROCESSES FOR PREPARING RALTEGRAVIR AND INTERMEDIATES IN THE PROCESSES
(FR) PROCÉDÉS DE PRÉPARATION DU RALTÉGRAVIR ET DE SES INTERMÉDIAIRES DANS LESDITS PROCÉDÉS
Abstract: front page image
(EN)The present invention provides a process for preparing benzyl-2-(4-(4- fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2- ylcarbamate (RLT-8), a process for preparing Raltegravir via RLT-8, a process for preparing methyl 2-(2-(benzyloxycarbonylamino)propan-2-yl)-5 -hydroxy-1-methyl-6- oxo-1,6-dihydropyrimidine-4-carboxylate (RLT-7'), a process for preparing Raltegravir via RLT-7', and a process for preparing crystalline form V of Raltegravir potassium.
(FR)La présente invention concerne un procédé de préparation de benzyl-2-(4-(4- fluorobenzylcarbamoyl)-5-hydroxy-1-méthyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2- ylcarbamate (RLT-8), un procédé de préparation du Raltégravir via RLT-8, un procédé de préparation de méthyl 2-(2-(benzyloxycarbonylamino)propan-2-yl)-5 -hydroxy-1-methyl-6- oxo-1,6-dihydropyrimidine-4-carboxylate (RLT-7'), un procédé de préparation du Raltégravir via RLT-7', et un procédé de préparation de la forme cristalline V du potassium de Raltégravir.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)