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1. (WO2012103031) DETECTION OF GENETIC ABNORMALITIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/103031    International Application No.:    PCT/US2012/022261
Publication Date: 02.08.2012 International Filing Date: 23.01.2012
IPC:
C12Q 1/68 (2006.01)
Applicants: ARIOSA DIAGNOSTICS, INC. [US/US]; 5945 Optical Court San Jose, CA 95138 (US) (For All Designated States Except US).
OLIPHANT, Arnold [US/US]; (US) (For US Only).
SPARKS, Andrew [US/US]; (US) (For US Only).
SONG, Ken [US/US]; (US) (For US Only).
STUELPNAGEL, John [US/US]; (US) (For US Only)
Inventors: OLIPHANT, Arnold; (US).
SPARKS, Andrew; (US).
SONG, Ken; (US).
STUELPNAGEL, John; (US)
Agent: BRASHEARS, Sarah, J.; Convergent Law Group LLP 475 N. Whisman Road, Suite 400 Mountain View, CA 94043 (US)
Priority Data:
13/338,963 28.12.2011 US
13/316,154 09.12.2011 US
61/436,135 25.01.2011 US
61/436,132 25.01.2011 US
Title (EN) DETECTION OF GENETIC ABNORMALITIES
(FR) DÉTECTION D'ANOMALIES GÉNÉTIQUES
Abstract: front page image
(EN)The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells.
(FR)Cette invention concerne des systèmes de dosage et des procédés associés pour déterminer des anomalies génétiques dans des échantillons mixtes contenant l'ADN acellulaire provenant à la fois de cellules normales et de cellules génétiquement atypiques putatives. A titre d'exemples d'échantillons mixtes pouvant être analysés à l'aide des systèmes de dosage selon l'invention, il y a les échantillons contenant à la fois l'ADN acellulaire de la mère et du fœtus et les échantillons contenant l'ADN provenant de cellules normales et de cellules cancéreuses circulantes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)