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1. (WO2012102937) BENZ IMIDAZOLE COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/102937    International Application No.:    PCT/US2012/021898
Publication Date: 02.08.2012 International Filing Date: 19.01.2012
IPC:
C07D 213/75 (2006.01), C07D 235/30 (2006.01), C07D 311/22 (2006.01), C07D 311/24 (2006.01), C07D 311/30 (2006.01), C07D 311/36 (2006.01), C07D 311/42 (2006.01), C07D 401/04 (2006.01), A61K 31/275 (2006.01), A61K 31/353 (2006.01), A61K 31/4184 (2006.01), A61K 31/435 (2006.01), C07C 255/57 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01), A61P 7/00 (2006.01)
Applicants: IRM LLC [US/US]; 131 Front Street P.O. Box HM 2899 Hamilton, HM LX (BM) (For All Designated States Except US).
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road La Jolla, CA 92037 (US) (For All Designated States Except US).
BOUCHEZ, Laure Christina [FR/US]; (US) (For US Only).
BOITANO, Anthony E. [US/US]; (US) (For US Only).
COOKE, Michael P. [US/US]; (US) (For US Only).
SCHULTZ, Peter G. [US/US]; (US) (For US Only)
Inventors: BOUCHEZ, Laure Christina; (US).
BOITANO, Anthony E.; (US).
COOKE, Michael P.; (US).
SCHULTZ, Peter G.; (US)
Agent: SMITH, Chihang Amy; Genomics Institute of the Novartis Research Foundation 10675 John Jay Hopkins Drive San Diego, CA 92121 (US)
Priority Data:
61/436,025 25.01.2011 US
Title (EN) BENZ IMIDAZOLE COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS
(FR) COMPOSÉS QUI DÉVELOPPENT DES CELLULES SOUCHES HÉMATOPOÏÉTIQUES
Abstract: front page image
(EN)The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
(FR)La présente invention concerne des composés et des compositions qui permettent le développement du nombre de cellules CD34+ pour la transplantation. L'invention concerne en outre une population cellulaire qui comporte des cellules souches hématopoïétiques (HSC) développées et son utilisation dans une autogreffe ou une homogreffe pour le traitement de patients atteints de maladies d'immunodéficience et de maladies auto-immunes héréditaires et de divers troubles hématopoïétiques pour reconstituer les lignées cellulaires hématopoïétiques et la défense du système immunitaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)