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Machine translation
1. (WO2012102900) COMPOSITIONS AND METHODS FOR PROVIDING OR MODULATING SWEET TASTE AND METHODS OF SCREENING THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/102900    International Application No.:    PCT/US2012/021498
Publication Date: 02.08.2012 International Filing Date: 17.01.2012
IPC:
A61K 38/00 (2006.01)
Applicants: MONELL CHEMICAL SENSES CENTER [US/US]; 3500 Market Street Philadelphia, PA 19104 (US) (For All Designated States Except US).
MARGOLSKEE, Robert, Franklin [US/US]; (US) (For US Only)
Inventors: MARGOLSKEE, Robert, Franklin; (US)
Agent: BAK, Mary, E; Howson & Howson LLP 501 Office Center Drive Suite 210 Fort Washington, PA 19034 (US)
Priority Data:
61/435,904 25.01.2011 US
Title (EN) COMPOSITIONS AND METHODS FOR PROVIDING OR MODULATING SWEET TASTE AND METHODS OF SCREENING THEREFOR
(FR) COMPOSITIONS ET PROCÉDÉS POUR APPORTER OU MODULER LE GOÛT SUCRÉ, ET PROCÉDÉS DE RECHERCHE SYSTÉMATIQUE S'Y RAPPORTANT
Abstract: front page image
(EN)The present invention provides methods for identifying a molecule that provides or enhances a sweet taste in the mouth and compositions containing such molecules. The methods involve determining the effect of a variety of known or new compounds on expression or functional activity of a glucose-transporter protein of the activity of an ATP-gated K+ channel (KATP) in a mammalian oral cell, taste cell, or heterologous cell that expresses the protein or channel.
(FR)La présente invention concerne des procédés permettant d'identifier une molécule qui apporte ou renforce un goût sucré dans la bouche, ainsi que des compositions contenant de telles molécules. Lesdits procédés consistent à déterminer l'effet de divers composés, connus ou nouveaux, sur l'expression ou l'activité fonctionnelle d'une protéine transporteuse du glucose de l'activité d'un canal potassium ATP-dépendant (KATP) dans une cellule mammalienne buccale, dans une cellule gustative, ou dans une cellule hétérologue qui exprime la protéine ou le canal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)