WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012102616) HETERODIRECTIONAL POLYNUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/102616    International Application No.:    PCT/NL2012/050046
Publication Date: 02.08.2012 International Filing Date: 27.01.2012
IPC:
C12N 15/10 (2006.01), C07H 21/04 (2006.01), C12N 15/11 (2006.01), C12N 15/113 (2010.01)
Applicants: FLEXGEN B.V. [NL/NL]; 72, Wassenaarseweg NL-2333 AL Leiden (NL) (For All Designated States Except US).
MATYSIAK, Stefan [DE/NL]; (NL) (For US Only).
HELLMUTH, Klaus [DE/NL]; (NL) (For US Only)
Inventors: MATYSIAK, Stefan; (NL).
HELLMUTH, Klaus; (NL)
Agent: DE LANG, R.J.; P.O. Box 3241 NL-2280 GE Rijswijk (NL)
Priority Data:
61/437,357 28.01.2011 US
Title (EN) HETERODIRECTIONAL POLYNUCLEOTIDES
(FR) POLYNUCLÉOTIDES HÉTÉRODIRECTIONNELS
Abstract: front page image
(EN)The current invention now allows the circularization of a polynucleotide via complementary motifs within the polynucleotide that can hybridize with each other, e.g. via classic Watson- Crick base pairing. This is achieved by having a heterodirectional design, i.e. a polynucleotide comprising at least one intramolecular switch, a 3'-3' or 5'-5' covalent linkage, such that the polynucleotide comprises at least two polynucleotide segments in opposite direction.
(FR)Cette invention permet désormais de circulariser un polynucléotide par l'intermédiaire de motifs complémentaires au sein dudit polynucléotide qui peuvent s'hybrider entre eux, par ex., par l'intermédiaire d'un appariement de bases de Watson-Crick classique. Pour ce faire, le polynucléotide a une conception hétérodirectionnelle, c'est-à-dire que le polynucléotide comprend au moins un commutateur intramoléculaire, une liaison covalente 3'-3' ou 5'-5', de façon à comprendre au moins deux segments polynucléotidiques dans des directions opposées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)