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1. (WO2012101619) A METHOD FOR EVALUATING A MENTAL DISORDER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/101619    International Application No.:    PCT/IL2011/000874
Publication Date: 02.08.2012 International Filing Date: 13.11.2011
IPC:
C12Q 1/68 (2006.01), C12Q 1/02 (2006.01), G06N 5/02 (2006.01)
Applicants: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY [IL/IL]; P. O. Box 653 84105 Beer Sheva (IL) (For All Designated States Except US).
BRODSKI, Claude [IL/IL]; (IL) (For US Only).
KOFMAN, Ora [IL/IL]; (IL) (For US Only).
JUKIC, Marin [HR/IL]; (IL) (For US Only)
Inventors: BRODSKI, Claude; (IL).
KOFMAN, Ora; (IL).
JUKIC, Marin; (IL)
Agent: PEARL COHEN ZEDEK LATZER; P.O Box 12704 46733 Herzlia (IL)
Priority Data:
61/435,373 24.01.2011 US
Title (EN) A METHOD FOR EVALUATING A MENTAL DISORDER
(FR) MÉTHODE D'ÉVALUATION D'UN TROUBLE MENTAL
Abstract: front page image
(EN)A method for evaluating the efficacy of a candidate drug for the treatment of a bipolar disorder is provided. The method includes administering the candidate drug or combination of drugs to a mouse characterized by an elevated amount of Otx2 protein in the hindbrain; and evaluating the extent, frequency and/or reversal of a mouse behaviour that is homologous to a bipolar disorder in a human.
(FR)Cette invention concerne une méthode d'évaluation de l'efficacité d'un candidat-médicament pour traiter un trouble bipolaire. La méthode comprend l'administration du candidat-médicament ou d'une association médicamenteuse à une souris caractérisée par une quantité élevée de protéine Otx2 dans le rhombencéphale ; et l'évaluation de l'étendue, de la fréquence et/ou de l'inversion d'un comportement murin qui est homologue à un trouble bipolaire chez l'homme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)