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1. (WO2012101246) METHODS AND MEANS FOR DIAGNOSING VASCULITIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/101246    International Application No.:    PCT/EP2012/051301
Publication Date: 02.08.2012 International Filing Date: 27.01.2012
IPC:
G01N 33/564 (2006.01)
Applicants: MEDIZINISCHE HOCHSCHULE HANNOVER [DE/DE]; Carl-Neuberg-Strasse 1 30625 Hannover (DE) (For All Designated States Except US).
WITTE, Torsten [DE/DE]; (DE) (For US Only).
BAERLECKEN, Niklas, Thomas [DE/DE]; (DE) (For US Only)
Inventors: WITTE, Torsten; (DE).
BAERLECKEN, Niklas, Thomas; (DE)
Agent: KRÖNCKE, Rolf; Gramm, Lins & Partner GbR Freundallee 13a 30173 Hannover (DE)
Priority Data:
11152361.9 27.01.2011 EP
Title (DE) Methods and means for diagnosing vasculitis
(EN) METHODS AND MEANS FOR DIAGNOSING VASCULITIS
(FR) MÉTHODES ET MOYENS POUR DIAGNOSTIQUER LA VASCULITE
Abstract: front page image
(DE)The present inventions relates generally to methods for diagnosing the presence or the risk of development or the therapy control of vasculitis, in particular, of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR) and Takayasu's arteritis in a subject, in particular, in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. The presence of antibodies against ferritin or immunoreactive peptides thereof is indicative for the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis. In particular, detection of the presence of antibodies against ferritin or immunoreactive peptides thereof, allows early diagnosis of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis.
(EN)The present inventions relates generally to methods for diagnosing the presence or the risk of development or the therapy control of vasculitis, in particular, of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR) and Takayasu's arteritis in a subject, in particular, in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. The presence of antibodies against ferritin or immunoreactive peptides thereof is indicative for the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis. In particular, detection of the presence of antibodies against ferritin or immunoreactive peptides thereof, allows early diagnosis of vasculitis, in particular of large vessel vasculitis, like GCA, PM R and Takayasu's arteritis.
(FR)De manière générale, cette invention concerne des méthodes pour diagnostiquer la présence, ou le risque de développement, ou le contrôle thérapeutique de la vasculite, en particulier, de la vasculite des gros vaisseaux, comme l'artérite giganto-cellulaire (GCA), la polymyalgia rheumatica (PMR) et l'artérite de Takayasu chez un sujet, en particulier, chez les mammifères. De plus, cette invention concerne des trousses d'essai utilisables pour diagnostiquer la présence, ou le risque de développement, ou pour le contrôle thérapeutique de la vasculite, en particulier, de la vasculite des gros vaisseaux, comme la GCA, la PMR et l'artérite de Takayasu, chez un sujet. En particulier, cette invention concerne une méthode pour diagnostiquer la présence, ou le risque de développement, ou pour le contrôle thérapeutique de la vasculite, en particulier, de la vasculite des gros vaisseaux, comme la GCA, la PMR et l'artérite de Takayasu, chez un sujet par la recherche de la présence d'anticorps contre la ferritine, en particulier, contre la ferritine à chaîne lourde ou des peptides immunoréactifs de celle-ci ou contre une protéine d'un analogue de ferritine, de préférence, une protéine d'un analogue de ferritine bactérienne, ou des peptides immunoréactifs de celle-ci, chez un sujet. La présence d'anticorps conte la ferritine ou des peptides immunoréactifs de celle-ci indique la présence ou le risque de développement, ou le contrôle thérapeutique de la vasculite, en particulier, de la vasculite des gros vaisseaux, comme la GCA, la PMR et l'artérite de Takayasu. En particulier, la détection de la présence d'anticorps contre la ferritine ou des peptides immunoréactifs de celle-ci permet le diagnostic précoce de la de la vasculite, en particulier, de la vasculite des gros vaisseaux, comme la GCA, la PMR et l'artérite de Takayasu.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)