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1. (WO2012101236) A PHOTOLUMINESCENT MOLECULAR COMPLEX AND METHOD FOR DETERMINING OF THE CONCENTRATION OF SAID MOLECULAR COMPLEX
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/101236    International Application No.:    PCT/EP2012/051275
Publication Date: 02.08.2012 International Filing Date: 26.01.2012
IPC:
C12Q 1/48 (2006.01), G01N 33/533 (2006.01), G01N 33/573 (2006.01), G01N 33/58 (2006.01), C07D 233/00 (2006.01), C07D 333/00 (2006.01), C07D 473/00 (2006.01)
Applicants: UNIVERSITY OF TARTU [EE/EE]; Ülikooli 18 EE-50090 Tartu (EE) (For All Designated States Except US).
URI, Asko [EE/EE]; (EE) (For US Only).
ENKVIST, Erki [EE/EE]; (EE) (For US Only).
VAASA, Angela [EE/EE]; (EE) (For US Only).
KASARI, Marje [EE/EE]; (EE) (For US Only)
Inventors: URI, Asko; (EE).
ENKVIST, Erki; (EE).
VAASA, Angela; (EE).
KASARI, Marje; (EE)
Agent: SARAP, Margus; Kompanii 1C EE-51004 Tartu (EE)
Priority Data:
11152289.2 26.01.2011 EP
Title (EN) A PHOTOLUMINESCENT MOLECULAR COMPLEX AND METHOD FOR DETERMINING OF THE CONCENTRATION OF SAID MOLECULAR COMPLEX
(FR) COMPLEXE MOLÉCULAIRE PHOTOLUMINESCENT ET PROCÉDÉ POUR DÉTERMINER LA CONCENTRATION DUDIT COMPLEXE MOLÉCULAIRE
Abstract: front page image
(EN)The invention concerns novel molecular complexes with photoluminescent probes whose specific association with purine-binding proteins leads to increased emission of long lifetime luminescence, and the application of the probes for monitoring activity of protein kinases (PKs) and other purine-binding proteins, screening of compounds as inhibitors of PKs and characterization of inhibitors targeted to the kinase, and methods of manufacturing of such probes. The invention concerns also the use of the improved method for monitoring activity of protein kinases in living cells, characterization of inhibitors of protein kinases, analysis of protein kinase-based disease biomarkers and other tasks of biological and medical importance.
(FR)Cette invention concerne de nouveaux complexes moléculaires avec des sondes photoluminescentes dont l'association spécifique avec des protéines se liant aux purines conduit à l'émission accrue d'une luminescence à longue durée de vie, et l'application desdites sondes pour surveiller l'activité des protéines kinases (PK) et d'autres protéines se liant aux purines, identifier par criblage les composés inhibiteurs de PK et caractériser les inhibiteurs ciblés sur la kinase, ainsi que des procédés de production desdites sondes. L'invention concerne également l'utilisation du procédé amélioré pour surveiller l'activité des protéines kinases dans des cellules vivantes, caractériser les inhibiteurs de protéines kinases, analyser les biomarqueurs de maladies médiées par les protéines kinases et d'autres tâches d'importance biologique et médicale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)